Computed Tomography Organ Dose Calculations - New tools and methods are being developed by using Monte Carlo transport technique to calculate organ dose for pediatric and adult patients undergoing computed tomography examinations. The organ dose estimates are being used for retrospective epidemiologic cohort and case-control studies Cancer Risks from CT Scan Use in the United States - We are estimating the potential radiation-related cancer risks that may be related to current levels of CT use in adults, and also conducting radiation risk-benefit analyses for CT screening examinations. Early Life Radiation and the Risk of Child Cancer - Studying radiation exposure during early life is of particular importance, given that many tissues are more susceptible to radiation effects in utero and at younger age of exposure. Results of our analysis, published in February 2011, showed some indication of a slight, non-significant increase in risk for all childhood cancer and leukemia with exposure to ionizing radiation in utero, and potential increased risk of lymphoma following exposure to x-rays in early infancy based on small numbers Pediatric CT Scans - REB initiated an international cohort study of 180,000 children to evaluate the potential risk of cancer associated with radiation exposure from pediatric CT scans. A comprehensive organ CT dose database was developed in support of a study of pediatric cancer risk and CT exposure. The results from this study published in 2012 suggested for the first time that there are increased risks of leukemia and brain tumors after CT scans in childhood. Pooled Analysis of Radiation-Related Brain Tumors - Preliminary arrangements have been made to conduct a pooled analysis of the risk of radiation-related malignant and benign brain tumors, including data from studies worldwide that have information on radiation dose to the brain for individuals Molecular and Histopathologic Clues to the Understanding of Thyroid Cancer Incidence - Thyroid cancer incidence has increased significantly over the last few decades. We are evaluating whether alterations in molecular markers and histopathology of papillary carcinoma have changed over the last three decades, using thyroid tumor tissue collected from one US hospital. Molecular markers under investigation are BRAF, N-RAS, K-Ras, H-Ras, and RET/PTC. Pooled analysis of Radiation-Related Thyroid Cancer- To improve our understanding of the etiology of thyroid cancer, REB scientists have set up an international consortium to study radiogenic thyroid cancer in children and adults. Statistical models of the radiation dose-response will be assessed as well as potential interaction with gender, age at exposure, attained age, and time since exposure. Results for children were submitted for publication in 2012.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010222-02
Application #
8565477
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2012
Total Cost
$1,658,348
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Harbron, Richard W; Chapple, Claire-Louise; O'Sullivan, John J et al. (2017) Survival adjusted cancer risks attributable to radiation exposure from cardiac catheterisations in children. Heart 103:341-346
Journy, Neige M Y; Lee, Choonsik; Harbron, Richard W et al. (2017) Projected cancer risks potentially related to past, current, and future practices in paediatric CT in the United Kingdom, 1990-2020. Br J Cancer 116:109-116
Berrington de Gonzalez, Amy; Journy, Neige; Lee, Choonsik et al. (2017) No Association between Radiation Dose from Pediatric CT Scans and Risk of Subsequent Hodgkin Lymphoma. Cancer Epidemiol Biomarkers Prev 26:804-806
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Olerud, Hilde M; Toft, Benthe; Flatabø, Silje et al. (2016) Reconstruction of paediatric organ doses from axial CT scans performed in the 1990s - range of doses as input to uncertainty estimates. Eur Radiol 26:3026-33

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