Abstract

In the years since my laboratory at the NIDA IRP identified the sigma-1 receptor in 1982, many preclinical studies have shown that sigma-1 receptors and associated ligands are involved in stroke, amnesia, depression, cancer, Alzheimers disease, pain, and cocaine addiction. In this fiscal year, we have made a major discovery in the action of the sigma-1 receptor. We found that the sigma-1 receptor can interact with and change therefore the conformation of the dopamine transporter so that cocaine can be more efficiently block the dopamine uptake through the dopamine transporter. In addition, we found that the sigma-1 receptor agonist can potentiate the self-administration of cocaine. Thus, drugs that target the sigma-1 receptor may be of therapeutic value in treating cocaine addiction.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000206-32
Application #
9553202
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
32
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Tsai, Shang-Yi Anne; Su, Tsung-Ping (2017) Sigma-1 Receptors Fine-Tune the Neuronal Networks. Adv Exp Med Biol 964:79-83
Weng, Tzu-Yu; Tsai, Shang-Yi Anne; Su, Tsung-Ping (2017) Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases. J Biomed Sci 24:74
Weng, Tzu-Yu; Hung, Denise T; Su, Tsung-Ping et al. (2017) Loss of Sigma-1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense. Oxid Med Cell Longev 2017:4582135
Chuang, Jian-Ying; Kao, Tzu-Jen; Lin, Shu-Hui et al. (2017) Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury. Redox Biol 11:135-143
Hong, Weimin Conrad; Yano, Hideaki; Hiranita, Takato et al. (2017) The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. J Biol Chem 292:11250-11261
Lewis, Abasha; Tsai, Shang-Yi; Su, Tsung-Ping (2016) Detection of Isolated Mitochondria-Associated ER Membranes Using the Sigma-1 Receptor. Methods Mol Biol 1376:133-40
Yasui, Yuko; Su, Tsung-Ping (2016) Potential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and Methamphetamine. J Drug Alcohol Res 5:
Su, Tsung-Ping; Su, Tzu-Chieh; Nakamura, Yoki et al. (2016) The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems. Trends Pharmacol Sci 37:262-278
Su, Tzu-Chieh; Lin, Shu-Hui; Lee, Pin-Tse et al. (2016) The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury. Neuropharmacology 105:1-9
Williams, Abasha; Hayashi, Teruo; Wolozny, Daniel et al. (2016) The non-apoptotic action of Bcl-xL: regulating Ca(2+) signaling and bioenergetics at the ER-mitochondrion interface. J Bioenerg Biomembr 48:211-25

Showing the most recent 10 out of 44 publications