Drug-abusing women have higher rates of pregnancy complications and an increased incidence of infants with lower birth weights and higher rates of congenital malformations and mortality than are seen within the general population. In addition, there is an increased prevalence for longer hospitalization due to neonatal abstinence syndrome. The risk of adverse events in drug-exposed infants can be directly influenced by dose, class of abused substance and time of intrauterine exposure. In addition, poly-drug use may also have an effect on the developmental outcome of the fetus. To better understand the role illicit and licit substances have on the developing fetus, it is necessary that we develop improved methods of detection and gain a better understanding of the transport process involved in the transfer of drug across the placental membrane. Limited data are available correlating the relationships between maternaldrug concentration in plasma, urine, saliva, sweat and hair to amniotic fluid, cord blood, fetal urine, meconium and fetal hair. We have designed several studies to investigate maternal and fetal drug disposition in a variety of biological fluid and tissues. Each maternal specimen provides a history of drug exposure at different stages of gestation. Fetal specimens offer unique information about prenatal drug exposure. Meconium begins to be formed in the 13th week of gestation and hair in the last trimester. Each matrix offers the opportunity to determine if drug concentrations in different matrices relate to maternal and neonatal outcome measures. In addition, due to the low concentrations of drugs in fetal matrices, it is necessary to develop sensitive and selective methods for detecting these compounds. Analytical methods are being improved to offer more sensitive and reliable methods of detecting the parent drug and metabolites of opiates, including buprenorphine and methadone, cocaine, methamphetamine, cannabinoids and nicotine in a variety of maternal and infant specimens. One of the analytical challenges in measurement of drugs following in utero exposure is that drug and metabolite profiles in neonatal specimens may be quite different than those found in adult biological fluids. This may be especially true for premature infants.

Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2012
Total Cost
$313,881
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code
Eiden, Rina D; Molnar, Danielle S; Granger, Douglas A et al. (2015) Prenatal tobacco exposure and infant stress reactivity: role of child sex and maternal behavior. Dev Psychobiol 57:212-25
Himes, Sarah K; Dukes, Kimberly A; Tripp, Tara et al. (2015) Clinical sensitivity and specificity of meconium fatty acid ethyl ester, ethyl glucuronide, and ethyl sulfate for detecting maternal drinking during pregnancy. Clin Chem 61:523-32
Himes, Sarah K; Huo, Yanling; Siberry, George K et al. (2015) Meconium Atazanavir Concentrations and Early Language Outcomes in HIV-Exposed Uninfected Infants With Prenatal Atazanavir Exposure. J Acquir Immune Defic Syndr 69:178-86
Smith, Lynne M; Diaz, Sabrina; LaGasse, Linda L et al. (2015) Developmental and behavioral consequences of prenatal methamphetamine exposure: A review of the Infant Development, Environment, and Lifestyle (IDEAL) study. Neurotoxicol Teratol 51:35-44
Himes, Sarah K; Tassiopoulos, Katherine; Yogev, Ram et al. (2015) Antiretroviral Drugs in Meconium: Detection for Different Gestational Periods of Exposure. J Pediatr 167:305-11.e3
Himes, Sarah K; Wu, Julia W; Jacobson, Denise L et al. (2015) Meconium Tenofovir Concentrations and Growth and Bone Outcomes in Prenatally Tenofovir Exposed HIV-Uninfected Children. Pediatr Infect Dis J 34:851-7
Schuetze, Pamela; Lessard, Jared; Colder, Craig R et al. (2015) Physiological reactivity during object manipulation among cigarette-exposed infants at 9 months of age. Neurotoxicol Teratol 48:64-8
Himes, Sarah K; Concheiro, Marta; Scheidweiler, Karl B et al. (2014) Validation of a novel method to identify in utero ethanol exposure: simultaneous meconium extraction of fatty acid ethyl esters, ethyl glucuronide, and ethyl sulfate followed by LC-MS/MS quantification. Anal Bioanal Chem 406:1945-55
Himes, Sarah K; LaGasse, Linda L; Derauf, Chris et al. (2014) Risk of neurobehavioral disinhibition in prenatal methamphetamine-exposed young children with positive hair toxicology results. Ther Drug Monit 36:535-43
Diaz, Sabrina D; Smith, Lynne M; LaGasse, Linda L et al. (2014) Effects of prenatal methamphetamine exposure on behavioral and cognitive findings at 7.5 years of age. J Pediatr 164:1333-8

Showing the most recent 10 out of 69 publications