Abstract

Psychomotor stimulant drugs of abuse cause brain damage that is dependent on elevated body temperature. This year, we continued to examine brain and body temperature changes in relation to the permeability of brain-blood barrier (BBB) during exposure to meth-amphetamine (METH). Particularly, we examined expression of heat shock proteins during acute METH intoxication and established its close relation to brain temperature elevation (collaboration with Dr. Sharma, Uppsala University). We also initiated the study on penetration of HIV-like microparticles during acute METH intoxication (collaboration with Dr. Polesskaya, Rochester University);this study will clarify why METH addiction greatly increases the probability of neuro-AIDS and will examine the role of temperature-dependent leakage of the blood-brain barrier in brain entry of virus-like particles. We also examined alterations of brain temperature homeostasis induced by lypopolysaccharides, an exogenous neurotoxin that could potentiate the adverse effects of addictive drugs (J. Tang).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000445-10
Application #
8148513
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2010
Total Cost
$303,533
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Solis, Ernesto; Cameron-Burr, Keaton T; Shaham, Yavin et al. (2017) Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature. Neuropsychopharmacology :
Kiyatkin, Eugene A; Ren, Suelynn E (2017) MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment. Curr Top Behav Neurosci 32:183-207
Solis Jr, Ernesto; Bola, R Aaron; Fasulo, Bradley J et al. (2017) Brain Hyperglycemia Induced by Heroin: Association with Metabolic Neural Activation. ACS Chem Neurosci 8:265-271
Bola, R Aaron; Kiyatkin, Eugene A (2016) Robust Brain Hyperglycemia during General Anesthesia: Relationships with Metabolic Brain Inhibition and Vasodilation. Front Physiol 7:39
Kiyatkin, Eugene A; Ren, Suelynn; Wakabayashi, Ken T et al. (2016) Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction. Neuropsychopharmacology 41:549-59
Kiyatkin, Eugene A; Sharma, Hari S (2016) Breakdown of Blood-Brain and Blood-Spinal Cord Barriers During Acute Methamphetamine Intoxication: Role of Brain Temperature. CNS Neurol Disord Drug Targets 15:1129-1138
Sharma, Hari Shanker; Kiyatkin, Eugene A; Patnaik, Ranjana et al. (2015) Exacerbation of Methamphetamine Neurotoxicity in Cold and Hot Environments: Neuroprotective Effects of an Antioxidant Compound H-290/51. Mol Neurobiol 52:1023-33
Kiyatkin, Eugene A; Kim, Albert H; Wakabayashi, Ken T et al. (2015) Effects of social interaction and warm ambient temperature on brain hyperthermia induced by the designer drugs methylone and MDPV. Neuropsychopharmacology 40:436-45
Carvalho, Félix; Kiyatkin, Eugene A; Rusyniak, Daniel E et al. (2015) Temperature in the spotlight of drug abuse research. Temperature (Austin) 2:27-8
Kiyatkin, Eugene A; Sharma, Hari S (2015) Not just the brain: methamphetamine disrupts blood-spinal cord barrier and induces acute glial activation and structural damage of spinal cord cells. CNS Neurol Disord Drug Targets 14:282-94

Showing the most recent 10 out of 27 publications