Psychomotor stimulant drugs of abuse cause brain damage that is dependent on elevated body temperature. This year, we continued to examine brain and body temperature changes during exposure to major active components of """"""""bath salts"""""""" (MDPV, Methylone) a new class of addictive drugs. We also comparing the effects of these drugs with those induced by other structurally similar analogs, particularly MDMA. We also continued our work with temperature effects of nicotine and we showed the critical role of peripheral actions of this drug in sensitization of hyperthermic effects induced by this drug.

Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2013
Total Cost
$155,877
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code
Bola, R Aaron; Kiyatkin, Eugene A (2016) Robust Brain Hyperglycemia during General Anesthesia: Relationships with Metabolic Brain Inhibition and Vasodilation. Front Physiol 7:39
Carvalho, Félix; Kiyatkin, Eugene A; Rusyniak, Daniel E et al. (2015) Temperature in the spotlight of drug abuse research. Temperature (Austin) 2:27-8
Kiyatkin, Eugene A; Ren, Suelynn; Wakabayashi, Ken T et al. (2015) Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction. Neuropsychopharmacology :
Sharma, Hari Shanker; Kiyatkin, Eugene A; Patnaik, Ranjana et al. (2015) Exacerbation of Methamphetamine Neurotoxicity in Cold and Hot Environments: Neuroprotective Effects of an Antioxidant Compound H-290/51. Mol Neurobiol :
Kiyatkin, Eugene A; Sharma, Hari S (2015) Not just the brain: methamphetamine disrupts blood-spinal cord barrier and induces acute glial activation and structural damage of spinal cord cells. CNS Neurol Disord Drug Targets 14:282-94
Kiyatkin, Eugene A; Kim, Albert H; Wakabayashi, Ken T et al. (2014) Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use. J Neurosci 34:7754-62
Kiyatkin, Eugene A; Kim, Albert H; Wakabayashi, Ken T et al. (2014) Effects of Social Interaction and Warm Ambient Temperature on Brain Hyperthermia Induced by the Designer Drugs Methylone and MDPV. Neuropsychopharmacology :
Lenoir, Magalie; Tang, Jeremy S; Woods, Amina S et al. (2013) Rapid sensitization of physiological, neuronal, and locomotor effects of nicotine: critical role of peripheral drug actions. J Neurosci 33:9937-49
Kiyatkin, Eugene A (2013) The hidden side of drug action: brain temperature changes induced by neuroactive drugs. Psychopharmacology (Berl) 225:765-80
Kiyatkin, Eugene A; Wakabayashi, Ken T; Lenoir, Magalie (2013) Physiological fluctuations in brain temperature as a factor affecting electrochemical evaluations of extracellular glutamate and glucose in behavioral experiments. ACS Chem Neurosci 4:652-65

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