Psychomotor stimulant drugs of abuse cause brain damage that is dependent on elevated body temperature. This year, we continued to examine brain and body temperature changes during exposure to major active components of "bath salts" (MDPV, Methylone) a new class of addictive drugs. We also comparing the effects of these drugs with those induced by other structurally similar analogs, particularly MDMA. We also continued our work with temperature effects of nicotine and we showed the critical role of peripheral actions of this drug in sensitization of hyperthermic effects induced by this drug.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Institute on Drug Abuse
Zip Code
Kiyatkin, Eugene A; Kim, Albert H; Wakabayashi, Ken T et al. (2014) Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use. J Neurosci 34:7754-62
Kiyatkin, Eugene A; Kim, Albert H; Wakabayashi, Ken T et al. (2014) Effects of Social Interaction and Warm Ambient Temperature on Brain Hyperthermia Induced by the Designer Drugs Methylone and MDPV. Neuropsychopharmacology :
Lenoir, Magalie; Tang, Jeremy S; Woods, Amina S et al. (2013) Rapid sensitization of physiological, neuronal, and locomotor effects of nicotine: critical role of peripheral drug actions. J Neurosci 33:9937-49
Kiyatkin, Eugene A (2013) The hidden side of drug action: brain temperature changes induced by neuroactive drugs. Psychopharmacology (Berl) 225:765-80
Sharma, Hari S; Kiyatkin, Eugene A (2009) Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: an experimental study using light and electron microscopy. J Chem Neuroanat 37:18-32
Kiyatkin, E A; Sharma, H S (2009) Permeability of the blood-brain barrier depends on brain temperature. Neuroscience 161:926-39
Brown, P Leon; Kiyatkin, Eugene A (2008) Sensory effects of intravenous cocaine on dopamine and non-dopamine ventral tegmental area neurons. Brain Res 1218:230-49
Kiyatkin, Eugene A (2008) Brain temperature responses to salient stimuli persist during dopamine receptor blockade despite a blockade of locomotor responses. Pharmacol Biochem Behav 91:233-42
Smirnov, Michael S; Kiyatkin, Eugene A (2008) Fluctuations in central and peripheral temperatures associated with feeding behavior in rats. Am J Physiol Regul Integr Comp Physiol 295:R1415-24