Abstract

Our previous work revealed that psychomotor stimulant drugs such as MDMA and methamphetamine induce robust changes in brain temperature. These hyperthermic effects are strongly potentiated by social interaction and warm environment--two conditions often associated with human drug use. In this year, we worked with morphine and oxycodone--two widely used analesic opioid drugs that are widely abused and could result in lethality during overdose. We also continued our work with fentanyl and showed that even small contamination of heroin with fentanyl results in dramatic potentiation of its temperature effects. By using multi-site temperature recordings, we clarified the role of metabolic brain activation and skin vascular response in mediating temperature effects of morphine and oxycodone in wide range of doses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000445-18
Application #
9770312
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Solis Jr, Ernesto; Bola, R Aaron; Fasulo, Bradley J et al. (2017) Brain Hyperglycemia Induced by Heroin: Association with Metabolic Neural Activation. ACS Chem Neurosci 8:265-271
Solis, Ernesto; Cameron-Burr, Keaton T; Shaham, Yavin et al. (2017) Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature. Neuropsychopharmacology :
Kiyatkin, Eugene A; Ren, Suelynn E (2017) MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment. Curr Top Behav Neurosci 32:183-207
Bola, R Aaron; Kiyatkin, Eugene A (2016) Robust Brain Hyperglycemia during General Anesthesia: Relationships with Metabolic Brain Inhibition and Vasodilation. Front Physiol 7:39
Kiyatkin, Eugene A; Ren, Suelynn; Wakabayashi, Ken T et al. (2016) Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction. Neuropsychopharmacology 41:549-59
Kiyatkin, Eugene A; Sharma, Hari S (2016) Breakdown of Blood-Brain and Blood-Spinal Cord Barriers During Acute Methamphetamine Intoxication: Role of Brain Temperature. CNS Neurol Disord Drug Targets 15:1129-1138
Kiyatkin, Eugene A; Kim, Albert H; Wakabayashi, Ken T et al. (2015) Effects of social interaction and warm ambient temperature on brain hyperthermia induced by the designer drugs methylone and MDPV. Neuropsychopharmacology 40:436-45
Carvalho, Félix; Kiyatkin, Eugene A; Rusyniak, Daniel E et al. (2015) Temperature in the spotlight of drug abuse research. Temperature (Austin) 2:27-8
Kiyatkin, Eugene A; Sharma, Hari S (2015) Not just the brain: methamphetamine disrupts blood-spinal cord barrier and induces acute glial activation and structural damage of spinal cord cells. CNS Neurol Disord Drug Targets 14:282-94
Sharma, Hari Shanker; Kiyatkin, Eugene A; Patnaik, Ranjana et al. (2015) Exacerbation of Methamphetamine Neurotoxicity in Cold and Hot Environments: Neuroprotective Effects of an Antioxidant Compound H-290/51. Mol Neurobiol 52:1023-33

Showing the most recent 10 out of 27 publications