Abstract

Due to extremely severe cuts in budget and staffing, no progress was made on this research project during the reporting period. This is unfortunate, as this project had been - in previous years - one of our most productive research endeavors, resulting in a large number of publications in the peer-reviewed scientific literature. We are presently pursuing external research collaborations, especially with entities within the pharmaceutical industry, that may allow us to once again pursue this work and follow up on the promising findings that we had obtained in previous years on this project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000475-12
Application #
9353054
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Keck, Thomas M; Zou, Mu-Fa; Bi, Guo-Hua et al. (2014) A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict Biol 19:195-209
Li, Xia; Xi, Zheng-Xiong; Markou, Athina (2013) Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. Neuropharmacology 66:12-23
Keck, Thomas M; Yang, Hong-Ju; Bi, Guo-Hua et al. (2013) Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl) 229:253-65
Srivastava, Ratika; Xi, Zheng-Xiong; Gardner, Eliot L (2012) Cocaine-taking and cocaine-seeking behaviors in rats remain stable after systemic administration of GYKI 52466: a non-competitive AMPA receptor antagonist. Neurosci Lett 508:106-9
Gardner, Eliot L (2011) Addiction and brain reward and antireward pathways. Adv Psychosom Med 30:22-60
Li, Xia; Li, Jie; Gardner, Eliot L et al. (2010) Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. J Neurochem 114:1368-80
Xi, Zheng-Xiong; Kiyatkin, Michael; Li, Xia et al. (2010) N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats. Neuropharmacology 58:304-13
Xi, Zheng-Xiong; Li, Xia; Peng, Xiao-Qing et al. (2010) Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. J Neurochem 112:564-76
Peng, Xiao-Qing; Li, Jie; Gardner, Eliot L et al. (2010) Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats. Eur J Pharmacol 627:156-61
Xi, Zheng-xiong; Spiller, Krista; Gardner, Eliot L (2009) Mechanism-based medication development for the treatment of nicotine dependence. Acta Pharmacol Sin 30:723-39

Showing the most recent 10 out of 12 publications