Abstract

Two studies were conducted during this reporting period that we anticipate will be published in the next reporting period. In one study, we examined the neurochemical and neurotoxic effect of bath salts and trifluoromethyl ring-substituted analogs. These compounds are legal designer stimulant drugs. In addition, in collaboration with Dr. Huestis, weve found further evidence for the non-linear accumulation of MDMA in the rat, based on the simultaneous measurement of pharmacokinetic/pharmacodynamic parameters. This non-linear accumulation of drug is related to inhibition of MDMA metabolism, a mechanism that could contribute to the clinical toxicity of MDMA.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000523-04
Application #
8336472
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2011
Total Cost
$184,236
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Baumann, Michael H; Majumdar, Susruta; Le Rouzic, Valerie et al. (2018) Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace. Neuropharmacology 134:101-107
Solis Jr, Ernesto; Partilla, John S; Sakloth, Farhana et al. (2017) N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability. Neuropsychopharmacology 42:1950-1961
Elmore, Joshua S; Dillon-Carter, Ora; Partilla, John S et al. (2017) Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and Its Metabolites in Rats. Neuropsychopharmacology 42:649-660
Hoffman, Alexander F; Lycas, Matthew D; Kaczmarzyk, Jakub R et al. (2017) Disruption of hippocampal synaptic transmission and long-term potentiation by psychoactive synthetic cannabinoid 'Spice' compounds: comparison with ?9 -tetrahydrocannabinol. Addict Biol 22:390-399
Baumann, Michael H; Bukhari, Mohammad O; Lehner, Kurt R et al. (2017) Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs. Curr Top Behav Neurosci 32:93-117
McLaughlin, Gavin; Morris, Noreen; Kavanagh, Pierce V et al. (2017) Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone. Drug Test Anal 9:358-368
Shekar, Aparna; Aguilar, Jenny I; Galli, Greta et al. (2017) Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporter. J Chem Neuroanat 83-84:69-74
Prekupec, Matthew P; Mansky, Peter A; Baumann, Michael H (2017) Misuse of Novel Synthetic Opioids: A Deadly New Trend. J Addict Med 11:256-265
Baumann, Michael H (2016) The Changing Face of Recreational Drug Use. Cerebrum 2016:
Hutsell, Blake A; Baumann, Michael H; Partilla, John S et al. (2016) Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats. Eur Neuropsychopharmacol 26:288-297

Showing the most recent 10 out of 32 publications