Significant progress was made in the last reporting period, resulting in five publications. One of these papers was a review article published in Pharmacological Reviews, a very high impact journal. The publication of this paper reflects the overall impact of our collaborative work with Dr. Prisinzano on the synthesis and evaluation of compounds related to Salvinorin A. Our collaborative efforts with Dr. Rices group yielded three publications in high impact Medicinal Chemistry journals. Our work with Dr. Prisinzano led to ne publication in the Journal of Natural Products, a leading journal for this type of work. Several manuscripts are in preparation and should be published by the next reporting period.
| Sally, Elliott J; Xu, Heng; Dersch, Christina M et al. (2010) Identification of a novel ""almost neutral"" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor. Synapse 64:280-8 |
| Tidgewell, Kevin; Groer, Chad E; Harding, Wayne W et al. (2008) Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem 51:2421-31 |
| Xu, Heng; Wang, Xiaoying; Partilla, John S et al. (2008) Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors. Brain Res Bull 77:49-54 |
| Rutherford, John M; Wang, Jiabei; Xu, Heng et al. (2008) Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors. Peptides 29:1424-31 |
| Prisinzano, Thomas E; Rothman, Richard B (2008) Salvinorin A analogs as probes in opioid pharmacology. Chem Rev 108:1732-43 |
