In this year, we completed two major sub-projects. First, we employed glutamate-sensitive sensors coupled with high-speed amperometry to evaluate rapid changes in glutamate following exposure to natural arousing stimuli, cocaine and nicotine. Second, we employed glucose-sensitive sensors coupled with high-speed amperometry to evaluate rapid fluctuations in brain glucose levels following exposure to natural stimuli and drugs of abuse (cocaine and nicotine). We also initiated third project, in which we want to examine how glucose enters the brain after iv injections of several drugs of abuse with different mechanisms of action (cocaine, methamphetamine and MDPV). This work will be expanded during the next years to include more complicated behavioral paradigms that involve the use of addictive drugs.

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2013
Total Cost
$623,509
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code
Wakabayashi, Ken T; Spekterman, Laurence; Kiyatkin, Eugene A (2016) Experience-dependent escalation of glucose drinking and the development of glucose preference over fructose - association with glucose entry into the brain. Eur J Neurosci 43:1422-30
Bola, R Aaron; Kiyatkin, Eugene A (2016) Robust Brain Hyperglycemia during General Anesthesia: Relationships with Metabolic Brain Inhibition and Vasodilation. Front Physiol 7:39
Kiyatkin, Eugene A; Wakabayashi, Ken T (2015) Parsing glucose entry into the brain: novel findings obtained with enzyme-based glucose biosensors. ACS Chem Neurosci 6:108-16
Wakabayashi, Ken T; Myal, Stephanie E; Kiyatkin, Eugene A (2015) Fluctuations in nucleus accumbens extracellular glutamate and glucose during motivated glucose-drinking behavior: dissecting the neurochemistry of reward. J Neurochem 132:327-41
Wakabayashi, Ken T; Kiyatkin, Eugene A (2015) Central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine. Front Neurosci 9:42
Wakabayashi, Ken T; Kiyatkin, Eugene A (2015) Behavior-associated and post-consumption glucose entry into the nucleus accumbens extracellular space during glucose free-drinking in trained rats. Front Behav Neurosci 9:173
Wakabayashi, Ken T; Kiyatkin, Eugene A (2014) Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. J Neurochem 128:672-85
Kiyatkin, Eugene A (2014) Critical role of peripheral sensory systems in mediating the neural effects of nicotine following its acute and repeated exposure. Rev Neurosci 25:207-21
Lenoir, Magalie; Tang, Jeremy S; Woods, Amina S et al. (2013) Rapid sensitization of physiological, neuronal, and locomotor effects of nicotine: critical role of peripheral drug actions. J Neurosci 33:9937-49
Lenoir, Magalie; Kiyatkin, Eugene A (2013) Intravenous nicotine injection induces rapid, experience-dependent sensitization of glutamate release in the ventral tegmental area and nucleus accumbens. J Neurochem 127:541-51

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