Addiction and other neuropsychiatric diseases involve altered learning and decision-making. The mechanism of these alterations, the circuits affected, and their significance to behavior are not well understood. We are using an animal models of addiction, associative learning and decisions making to study the neural circuits mediating simple associative learning and decision-making and to identify critical changes that may underlie addiction and other co-morbid neuropsychiatric disorders. It is hoped that by better understanding these changes, we will have better models for intervention.

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2013
Total Cost
$3,128,401
Indirect Cost
Name
National Institute on Drug Abuse
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Type
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McDannald, Michael A; Esber, Guillem R; Wegener, Meredyth A et al. (2014) Orbitofrontal neurons acquire responses to 'valueless' Pavlovian cues during unblocking. Elife 3:e02653
Berg, Benjamin A; Schoenbaum, Geoffrey; McDannald, Michael A (2014) The dorsal raphe nucleus is integral to negative prediction errors in Pavlovian fear. Eur J Neurosci 40:3096-101
Wilson, Robert C; Takahashi, Yuji K; Schoenbaum, Geoffrey et al. (2014) Orbitofrontal cortex as a cognitive map of task space. Neuron 81:267-79
Lucantonio, Federica; Takahashi, Yuji K; Hoffman, Alexander F et al. (2014) Orbitofrontal activation restores insight lost after cocaine use. Nat Neurosci 17:1092-9
Lucantonio, Federica; Caprioli, Daniele; Schoenbaum, Geoffrey (2014) Transition from 'model-based' to 'model-free' behavioral control in addiction: Involvement of the orbitofrontal cortex and dorsolateral striatum. Neuropharmacology 76 Pt B:407-15
Schoenbaum, Geoffrey; Esber, Guillem R; Iordanova, Mihaela D (2013) Dopamine signals mimic reward prediction errors. Nat Neurosci 16:777-9
McDannald, Michael A; Jones, Joshua L; Takahashi, Yuji K et al. (2013) Learning theory: A driving force in understanding orbitofrontal function. Neurobiol Learn Mem :
Schoenbaum, Geoffrey; Stalnaker, Thomas A; Niv, Yael (2013) How did the chicken cross the road? With her striatal cholinergic interneurons, of course. Neuron 79:3-6