Obesity and diabetes are more common in African-Americans than whites. Because free fatty acids (FFA) participate in the development of these conditions, studying race differences in the regulation of FFA and glucose by insulin is essential. Background: Quantitative evaluation of insulin regulation on plasma glucose and free fatty acid (FFA) in response to external glucose challenge is clinically important to assess the development of insulin resistance. Mathematical minimal models (MMs) based on insulin modified frequently-sampled intravenous glucose tolerance tests (IM-FSIGT) are widely applied to ascertain an insulin sensitivity index. However, the action of insulin on FFA kinetics is not considered in most MMs. Neither glucose clamps nor IM-FSIGT are normal physiological conditions so it is important to quantify insulin modulation of glucose and FFA metabolism in postprandial state. Methods: Assessing post-prandial insulin secretion rate and insulin clearance in Dr. Sumner's Federal Womens cohort. Recruitment is going well and Dr. Chung indicates that they will complete data collection on 55 of the 66 women by the end of May 2016. This is an important study to identify the causes of postprandial hyperinsulinemia in women of African descent. We are also working with Dr. Sumner's group in analyzing Vitamin D levels in connection with bone density and thyroid hormone.

Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2016
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
Zip Code
Li, Yanjun; Chow, Carson C; Courville, Amber B et al. (2016) Modeling glucose and free fatty acid kinetics in glucose and meal tolerance test. Theor Biol Med Model 13:8
Thoreson, Caroline K; Chung, Stephanie T; Ricks, Madia et al. (2015) Biochemical and clinical deficiency is uncommon in African immigrants despite a high prevalence of low vitamin D: the Africans in America study. Osteoporos Int 26:2607-2615
Adler-Wailes, Diane C; Periwal, Vipul; Ali, Asem H et al. (2013) Sex-associated differences in free fatty acid flux of obese adolescents. J Clin Endocrinol Metab 98:1676-84
Heuett, William J; Miller 3rd, Bernard V; Racette, Susan B et al. (2012) Bayesian functional integral method for inferring continuous data from discrete measurements. Biophys J 102:399-406
Chow, Carson C; Periwal, Vipul; Csako, Gyorgy et al. (2011) Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. J Clin Endocrinol Metab 96:2456-63
Periwal, Vipul; Chow, Carson C; Bergman, Richard N et al. (2008) Evaluation of quantitative models of the effect of insulin on lipolysis and glucose disposal. Am J Physiol Regul Integr Comp Physiol 295:R1089-96