Computational modeling of human metabolism, body weight and composition

Hall, Kevin

Abstract

We continue to develop mathematical models of human macronutrient metabolism and have conducted several validation studies using a variety of published data on the metabolic responses to overfeeding, underfeeding, and isocaloric changes in dietary macronutrients. The model has been deployed as a clinical research tool in collaboration with NIH clinical investigators to help design prospective studies as well as plan and track clinical weight management programs. Our models are being applied to a variety of problems, from calculating the relationship between human weight change and food intake to calculating the progressive increase of US food waste.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIADK013036-04
• Application #: 8148671
• Support Year: 4
• Fiscal Year: 2010
• Total Cost: $356,095

Institution

• Name: National Institute of Diabetes and Digestive and Kidney Diseases

Publications

Guo, Juen; Brager, Danielle C; Hall, Kevin D (2018) Simulating long-term human weight-loss dynamics in response to calorie restriction. Am J Clin Nutr 107:558-565

Hall, Kevin D; Kahan, Scott (2018) Maintenance of Lost Weight and Long-Term Management of Obesity. Med Clin North Am 102:183-197

Hall, Kevin D; Schoeller, Dale A; Brown, Andrew W (2018) Reducing Calories to Lose Weight. JAMA 319:2336-2337

Hall, Kevin D; Sanghvi, Arjun; Göbel, Britta (2017) Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy. Obesity (Silver Spring) 25:2088-2091

Hall, Kevin D; Guo, Juen (2017) Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition. Gastroenterology 152:1718-1727.e3

Katan, Martijn B; de Ruyter, Janne C; Kuijper, Lothar D J et al. (2016) Impact of Masked Replacement of Sugar-Sweetened with Sugar-Free Beverages on Body Weight Increases with Initial BMI: Secondary Analysis of Data from an 18 Month Double-Blind Trial in Children. PLoS One 11:e0159771

MacLeod, Erin L; Hall, Kevin D; McGuire, Peter J (2016) Computational modeling to predict nitrogen balance during acute metabolic decompensation in patients with urea cycle disorders. J Inherit Metab Dis 39:17-24

Polidori, David; Sanghvi, Arjun; Seeley, Randy J et al. (2016) How Strongly Does Appetite Counter Weight Loss? Quantification of the Feedback Control of Human Energy Intake. Obesity (Silver Spring) 24:2289-2295

Freedhoff, Yoni; Hall, Kevin D (2016) Weight loss diet studies: we need help not hype. Lancet 388:849-51

Sanghvi, Arjun; Redman, Leanne M; Martin, Corby K et al. (2015) Validation of an inexpensive and accurate mathematical method to measure long-term changes in free-living energy intake. Am J Clin Nutr 102:353-8