Overconsumption of foods that result from extensive industrial processing is believed to contribute to the development of obesity. Ultra-processed foods now represent most of the calories consumed in America and their contribution to overall diet has increased in parallel with the rise in the prevalence of obesity over the past several decades. While such correlations are suggestive, the effect of industrial processing per se, independent of dietary macronutrient composition, on ad libitum energy intake has not been carefully investigated. Therefore, we have initiated a feeding study in 20 adult men and women to investigate the differences in ad libitum energy intake resulting from consuming two test diets for a pair of 2-week periods in a randomized, crossover design during a single 4-week period. The test diets presented to participants will be matched for calories, macronutrient composition, sugar, fiber, and sodium, but one diet will be composed of ultra-processed foods whereas the other diet will be unprocessed foods.

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U.S. National Inst Diabetes/Digst/Kidney
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Hall, Kevin D; Chung, Stephanie T (2018) Low-carbohydrate diets for the treatment of obesity and type 2 diabetes. Curr Opin Clin Nutr Metab Care 21:308-312
Hall, Kevin D; Guyenet, Stephan J; Leibel, Rudolph L (2018) The Carbohydrate-Insulin Model of Obesity Is Difficult to Reconcile With Current Evidence. JAMA Intern Med 178:1103-1105
Hall, Kevin D; Guo, Juen (2017) Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition. Gastroenterology 152:1718-1727.e3
Hall, K D (2017) A review of the carbohydrate-insulin model of obesity. Eur J Clin Nutr 71:323-326
Hall, Kevin D; Chen, Kong Y; Guo, Juen et al. (2016) Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men. Am J Clin Nutr 104:324-33
Freedhoff, Yoni; Hall, Kevin D (2016) Weight loss diet studies: we need help not hype. Lancet 388:849-51
Hall, Kevin D (2015) Prescribing low-fat diets: useless for long-term weight loss? Lancet Diabetes Endocrinol 3:920-1
Hall, Kevin D; Bemis, Thomas; Brychta, Robert et al. (2015) Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity. Cell Metab 22:427-36
Simmons, W Kyle; Rapuano, Kristina M; Ingeholm, John E et al. (2014) The ventral pallidum and orbitofrontal cortex support food pleasantness inferences. Brain Struct Funct 219:473-83
Schoeller, Dale A; Thomas, Diana; Archer, Edward et al. (2013) Self-report-based estimates of energy intake offer an inadequate basis for scientific conclusions. Am J Clin Nutr 97:1413-5

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