We created a mathematical model of mouse energy metabolism that provides a quantitative framework for investigating energy balance relationships in mouse models of obesity and diabetes. We are now investigating body weight regulation of mice subjected to various ad libitum diets inducing weight gain and loss. We are particularly interested in the role of striatal dopamine signaling in food intake and physical activity behavior and we are studying mice with a knockout of the dopamine type 2 receptor specifically in the striatum.

Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2013
Total Cost
$143,548
Indirect Cost
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Bond, Nichole D; Guo, Juen; Hall, Kevin D et al. (2016) Modeling Energy Dynamics in Mice with Skeletal Muscle Hypertrophy Fed High Calorie Diets. Int J Biol Sci 12:617-30
Devarakonda, Kavya; Nguyen, Katrina P; Kravitz, Alexxai V (2015) ROBucket: A low cost operant chamber based on the Arduino microcontroller. Behav Res Methods :
Hall, Kevin D (2012) Metabolism of mice and men: mathematical modeling of body weight dynamics. Curr Opin Clin Nutr Metab Care 15:418-23
Guo, Juen; Hall, Kevin D (2011) Challenges of indirect calorimetry in mice. Am J Physiol Regul Integr Comp Physiol 300:R780; author reply R781-2
Guo, Juen; Hall, Kevin D (2011) Predicting changes of body weight, body fat, energy expenditure and metabolic fuel selection in C57BL/6 mice. PLoS One 6:e15961
Jo, Junghyo; Guo, Juen; Liu, Teresa et al. (2010) Hypertrophy-driven adipocyte death overwhelms recruitment under prolonged weight gain. Biophys J 99:3535-44
Hall, Kevin D (2010) Mathematical modelling of energy expenditure during tissue deposition. Br J Nutr 104:4-7
Guo, Juen; Jou, William; Gavrilova, Oksana et al. (2009) Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic diets. PLoS One 4:e5370