Erythroid diseases associated with pathological growth include anemias, polycythemia, and erythroleukemia. In addition, there is evidence that several other disease entities that share a common feature of ineffective erythropoiesis are manifested by dysregulated erythroblast growth and apoptosis. The project includes the identification and characterization of growth-regulating genes and proteins that are expressed during erythropoiesis. In addition, small molecule screens are being preformed to identify candidate molecules that modulate the effects of erythropoietin upon erythroblast growth and differentiation. A focus of this project involves screening and characterization of adenosine and related derivative molecules for their potential to inhibit erythroblast growth and differentiation.
| Tanno, Toshihiko; Miller, Jeffery L (2011) [GDF15 expression and iron overload in ineffective erythropoiesis]. Rinsho Ketsueki 52:387-98 |
| Noh, Seung-Jae; Miller, Samuel H; Lee, Y Terry et al. (2009) Let-7 microRNAs are developmentally regulated in circulating human erythroid cells. J Transl Med 7:98 |
| Bhanu, Natarajan V; Lee, Y Terry; Oneal, Patricia A et al. (2008) Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. Biochim Biophys Acta 1782:504-10 |
