A major mission of this group involves the management and service of three NMR spectrometers that are used by NIH scientists, primarily but not exclusively those of the Laboratory of Bioorganic Chemistry, for the identification of natural and synthetic products, tertiary structure determination, binding assays, and molecular dynamics. Management and service include 1) troubleshooting and servicing NMR spectometers, 2) provide technical assistance and data interpretation, 3) teach investigators NMR techniques that can aid their research goals, and 4) engage in collaborative research projects in support of organizational missions.

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Project End
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Support Year
19
Fiscal Year
2016
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
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Yin, Qian; Abendschein, Dana; Muccigrosso, David et al. (2017) A non-contrast CMR index for assessing myocardial fibrosis. Magn Reson Imaging 42:69-73
Liu, Hong-Bing; Lauro, Gianluigi; O'Connor, Robert D et al. (2017) Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge. J Nat Prod 80:2556-2560
O'Connor, Robert D; Singh, Manmilan; Chang, James et al. (2017) Dual Mode of Action for Plusbacin A3 in Staphylococcus aureus. J Phys Chem B 121:1499-1505
Shahzad-Ul-Hussan, Syed; Sastry, Mallika; Lemmin, Thomas et al. (2017) Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins. Chembiochem 18:764-771
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Dogo-Isonagie, Cajetan; Lee, Su-Lin; Lohith, Katheryn et al. (2016) Design and synthesis of small molecule-sulfotyrosine mimetics that inhibit HIV-1 entry. Bioorg Med Chem 24:1718-28
Airhart, Sophia; Cade, W Todd; Jiang, Hui et al. (2016) A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study. J Clin Endocrinol Metab 101:504-12
Liu, Hongbing; Lohith, Katheryn; Rosario, Margaret et al. (2016) Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity. J Nat Prod 79:1872-6
Tosh, Dilip K; Ciancetta, Antonella; Warnick, Eugene et al. (2016) Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists. J Med Chem 59:3249-63
Fang, Zhong-Ze; Tosh, Dilip K; Tanaka, Naoki et al. (2015) Metabolic mapping of A3 adenosine receptor agonist MRS5980. Biochem Pharmacol 97:215-23

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