Specific endocrine syndromes are produced in response to benign and malignant tumors of endocrine tissue. We have been part of a collaborative group in the Clinical Center, NCI, and NINDS. We study patients with acromegaly in collaboration with Dr. Edward Oldfield of NINDS. These studies consist of careful phenotypic characterization of the patient followed by surgery to remove the adenoma. This is followed by histologic and molecular genetic characterization so that phenotypic-genotypic characterization can be made. The second group of studies is in collaboration with Dr. Electron Kebebew in which a similar group of phenotypic-genotypic characterization is underway. In addition, Clinical Center Radiology is involved in collaboration to localize the pancreatic tumors for surgical localization. These tumors have also been used as a resource by other investigators in NIDDK, by other institutes and by NCI pathology.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2011
Total Cost
$341,029
Indirect Cost
City
State
Country
Zip Code
Nockel, Pavel; Babic, Bruna; Millo, Corina et al. (2017) Localization of Insulinoma Using 68Ga-DOTATATE PET/CT Scan. J Clin Endocrinol Metab 102:195-199
Babic, Bruna; Keutgen, Xavier; Nockel, Pavel et al. (2016) Insulinoma Due to Multiple Pancreatic Microadenoma Localized by Multimodal Imaging. J Clin Endocrinol Metab 101:3559-3563
Butler, Peter W; Cochran, Craig S; Merino, Maria J et al. (2012) Ectopic growth hormone-releasing hormone secretion by a bronchial carcinoid tumor: clinical experience following tumor resection and long-acting octreotide therapy. Pituitary 15:260-5
Guettier, Jean-Marc; Gorden, Phillip (2010) Insulin secretion and insulin-producing tumors. Expert Rev Endocrinol Metab 5:217-227
Solomon, Benjamin D; Lange, Eileen; Shubrook, Jay et al. (2010) Deletion of 8q24 in an adult with mild dysmorphic features, developmental delay, and ketotic hypoglycemia. Am J Med Genet A 152A:1545-9
Shin, Joyce J; Gorden, Phillip; Libutti, Steven K (2010) Insulinoma: pathophysiology, localization and management. Future Oncol 6:229-37
Guettier, Jean-Marc; Kam, Anthony; Chang, Richard et al. (2009) Localization of insulinomas to regions of the pancreas by intraarterial calcium stimulation: the NIH experience. J Clin Endocrinol Metab 94:1074-80
Mathur, Aarti; Gorden, Philip; Libutti, Steven K (2009) Insulinoma. Surg Clin North Am 89:1105-21
Lodish, Maya B; Powell, Anathea C; Abu-Asab, Mones et al. (2008) Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. J Clin Endocrinol Metab 93:1123-8