We are conducting a cross-sectional, case-controlled study of energy expenditure in subjects with narcolepsy, who will be individually matched with healthy controls. The primary objectives of this study is to determine whether hypocretin-deficient subjects with narcolepsy have lower energy expenditure as determined by a 24h stay in the metabolic chamber. During an inpatient visit of approximately 3-4 weeks following screening and medication washout the following additional parameters will be assessed: physical activity (by doubly labeled water study and activity monitors);food intake (dietary history, experimental in-house buffet and food vending machines with computerized access code), body composition (dexa measurements and abdomen CT);measurements of cutaneous and core body temperature and heart rate variability, both indirect indices of autonomic nervous system activity. Endocrine in-depth characterization will include insulin resistance (oral and iv glucose tolerance test), leptin and gh-relin levels as well as characterization of the main neuroendocrine axes.

Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2012
Total Cost
$213,116
Indirect Cost
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State
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Collins, Allan J; Foley, Robert N; Chavers, Blanche et al. (2014) US Renal Data System 2013 Annual Data Report. Am J Kidney Dis 63:A7
Collins, Allan J; Foley, Robert N; Herzog, Charles et al. (2013) US Renal Data System 2012 Annual Data Report. Am J Kidney Dis 61:A7, e1-476
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Cizza, G; Requena, M; Galli, G et al. (2011) Chronic sleep deprivation and seasonality: implications for the obesity epidemic. J Endocrinol Invest 34:793-800
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