Genes associated with endocrine tumorigenesis

Agarwal, Sunita

Abstract

Functional inactivation of menin, encoded by the MEN1 gene, causes the inherited multiple endocrine neoplasia type 1 (MEN1) syndrome and some but not all sporadic pancreatic endocrine tumors. Therefore, unraveling molecular events upstream or downstream of menin could point to other causative genes and/or regulatory events responsible for such tumor types. Proper tissue differentiation is dependent upon a precise control over the coordination between cell cycle events and the expression and activity of tissue specifying factors. This type of coordination could go awry to result in tumor formation. Our current efforts are directed towards studying 2 categories of genes for menin-regulated transcriptional, post-transcriptional, protein:protein interaction, and sub-cellular localization events: 1) Cyclin-dependent kinases and their inhibitors, and 2) Endocrine pancreas differentiation factors.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIADK075035-03
• Application #: 8349949
• Support Year: 3
• Fiscal Year: 2011
• Total Cost: $1,017,065

Institution

• Name: National Institute of Diabetes and Digestive and Kidney Diseases

Publications

Parekh, Vaishali I; Modali, Sita D; Welch, James et al. (2018) Frequency and consequence of the recurrent YY1 p.T372R mutation in sporadic insulinomas. Endocr Relat Cancer 25:L31-L35

Thakur, Shilpa; Daley, Brianna; Gaskins, Kelli et al. (2018) Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo. Clin Cancer Res 24:4030-4043

Agarwal, Sunita K (2017) The future: genetics advances in MEN1 therapeutic approaches and management strategies. Endocr Relat Cancer 24:T119-T134

Iyer, Sucharitha; Modali, Sita D; Agarwal, Sunita K (2017) Long Noncoding RNA MEG3 Is an Epigenetic Determinant of Oncogenic Signaling in Functional Pancreatic Neuroendocrine Tumor Cells. Mol Cell Biol 37:

Keutgen, Xavier M; Nilubol, Naris; Agarwal, Sunita et al. (2016) Reoperative Surgery in Patients with Multiple Endocrine Neoplasia Type 1 Associated Primary Hyperparathyroidism. Ann Surg Oncol :

Guan, Bin; Welch, James M; Sapp, Julie C et al. (2016) GCM2-Activating Mutations in Familial Isolated Hyperparathyroidism. Am J Hum Genet 99:1034-1044

Gara, Sudheer Kumar; Jia, Li; Merino, Maria J et al. (2015) Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer. N Engl J Med 373:448-55

Parekh, Vaishali I; Modali, Sita D; Desai, Shruti S et al. (2015) Consequence of Menin Deficiency in Mouse Adipocytes Derived by In Vitro Differentiation. Int J Endocrinol 2015:149826

Modali, Sita D; Parekh, Vaishali I; Kebebew, Electron et al. (2015) Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors. Mol Endocrinol 29:224-37

Desai, Shruti S; Kharade, Sampada S; Parekh, Vaishali I et al. (2015) Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b). J Biol Chem 290:25595-608