The focus is to improved spatial resolution in coronary imaging and has resulted in the development of a high magnetic field MR method that allows imaging of atherosclerotic coronary artery disease at an unprecedented MR in-plane resolution of 350 m. This method allows coronary imaging with an order of magnitude reduction in voxel size vs routine state-of-the-art imaging. Preliminary experience indicates this is a functional technique even in patients with significant coronary artery disease where flow based signal to noise is compromised. Moreover, since this is without ionizing radiation it is potentially useful for young subjects and monitoring of therapy More recently we have developed a noninvasive coronary vessel wall imaging method utilizing time-resolved (20 milliseconds) dynamic imaging that allows for a more robust technique to visualize and quantify the thickness of the walls of coronary arteries. This technique is less affected by motion related distortions and is therefore able to more reliably detect early coronary artery thickening, a progressive morphologic step in CAD development. This technique is dubbed TRAPD (Time Resolved Acquisition of Phase sensitive Dual inversion recovery). This is a unique non-invasive method available with the potential to characterize and study coronary artery disease in humans and its response to various lipid lowering and anti-inflammatory therapies. The application of these methods describe CT/MRI defined coronary abnormalities in patients with HIV and was utilized to quantify the atherosclerotic plaque burden in patients with Cushings Syndrome.

Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2013
Total Cost
$380,408
Indirect Cost
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State
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Morse, Caryn G; McLaughlin, Mary; Matthews, Lindsay et al. (2015) Nonalcoholic Steatohepatitis and Hepatic Fibrosis in HIV-1-Monoinfected Adults With Elevated Aminotransferase Levels on Antiretroviral Therapy. Clin Infect Dis 60:1569-78
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Ohayon, Jacques; Finet, Gérard; Le Floc'h, Simon et al. (2014) Biomechanics of atherosclerotic coronary plaque: site, stability and in vivo elasticity modeling. Ann Biomed Eng 42:269-79
Riou, Laurent M; Broisat, Alexis; Ghezzi, Catherine et al. (2014) Effects of mechanical properties and atherosclerotic artery size on biomechanical plaque disruption - mouse vs. human. J Biomech 47:765-72
Abd-Elmoniem, Khaled Z; Bondy, Carolyn A; Gharib, Ahmed M (2014) The relation between X chromosome parental origin and aortic stiffness in patients with Turner's syndrome: role of hypertension and antihypertensive drugs. Clin Endocrinol (Oxf) :
Abd-Elmoniem, Khaled Z; Unsal, Aylin B; Eshera, Sarah et al. (2014) Increased coronary vessel wall thickness in HIV-infected young adults. Clin Infect Dis 59:1779-86
Gutin, Liat S; Merz, Alexa E; Bakalov, Vladimir K et al. (2013) Parity and aortic dimensions in healthy women. Int J Cardiol 165:383-4

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