We did a clinical trial of succimer to treat moderately lead poisoned children. We found no effect of succimer treatment on cognition or behavior, reported previously. Recently, we have arranged with CDC to analyze blood samples collected in this project for methyl mercury, inorganic mercury, and cadmium, which allowed a randomized trial of succimer for chelation of these compounds without enrolling any new subjects or collecting any specimens. Succimer does not appear to be an efficacious chelating agent for mercury or cadmium.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Zip Code
Wang, Yan; Chen, Aimin; Dietrich, Kim N et al. (2014) Postnatal exposure to methyl mercury and neuropsychological development in 7-year-old urban inner-city children exposed to lead in the United States. Child Neuropsychol 20:527-38
Liu, Jianghong; Liu, Xianchen; Wang, Wei et al. (2014) Blood lead concentrations and children's behavioral and emotional problems: a cohort study. JAMA Pediatr 168:737-45
Cao, Yang; Chen, Aimin; Bottai, Matteo et al. (2013) The impact of succimer chelation on blood cadmium in children with background exposures: a randomized trial. J Pediatr 163:598-600
Cao, Yang; Chen, Aimin; Jones, Robert L et al. (2010) Does background postnatal methyl mercury exposure in toddlers affect cognition and behavior? Neurotoxicology 31:1-9
Rogan, Walter J; Brady, Michael T; Committee on Environmental Health et al. (2009) Drinking water from private wells and risks to children. Pediatrics 123:e1123-37
Committee on Environmental Health; Committee on Infectious Diseases; Rogan, Walter J et al. (2009) Drinking water from private wells and risks to children. Pediatrics 123:1599-605