In the mid-1980s we carried out a prospective study of early pregnancy in which we enrolled 221 health women who were planning to become pregnant. These women collected daily urine specimens for up to six months. We've assayed these specimens to describe the hormonal events of the menstrual cycle and early pregnancy. 155 women became clinically pregnant during the study, while 44 had pregnancies that ended so early that the pregnancies were detectable only by assay of urinary human chorionic gonadotropin. This unique study has been called a landmark, and continues to provide a rich resource for the description of the earliest stages of pregnancy. (More than 30,000 urine samples are still being stored.) We've published 50 papers from this study over the past two decades, some of which have led to new understanding of the fundamental processes of conception and early pregnancy. In addition, we have continued to make use of large population registries in order to pursue basic questions on pregnancy and maternal and infant health. We have worked especially closely with Norwegian colleagues in the analysis of the Norwegian Medical Birth Registry. Last year's progress. We have begun a study of events during pregnancy and the subsequent risk of cerebral palsy, based within the two national birth cohorts of Norway and Denmark. This study, in collaboration with Norwegian and Danish researchers will identify approximately 350 children with cerebral palsy whose mothers were enrolled in the two birth cohorts. This is by far the largest cohort study of cerebral palsy ever conducted, and will allow biological specimens collected during pregnancy to be used to identify exposures and early biological changes (such as inflammation) that may lead to cerebral palsy.

Project Start
Project End
Budget Start
Budget End
Support Year
35
Fiscal Year
2012
Total Cost
$520,720
Indirect Cost
City
State
Country
Zip Code
Jukic, Anne Marie; Calafat, Antonia M; McConnaughey, D Robert et al. (2016) Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss. Environ Health Perspect 124:321-8
DeRoo, Lisa; Skjærven, Rolv; Wilcox, Allen et al. (2016) Placental abruption and long-term maternal cardiovascular disease mortality: a population-based registry study in Norway and Sweden. Eur J Epidemiol 31:501-11
Kummet, Colleen M; Moreno, Lina M; Wilcox, Allen J et al. (2016) Passive Smoke Exposure as a Risk Factor for Oral Clefts-A Large International Population-Based Study. Am J Epidemiol 183:834-41
Tollånes, Mette C; Wilcox, Allen J; Stoltenberg, Camilla et al. (2016) Neurodevelopmental Disorders or Early Death in Siblings of Children With Cerebral Palsy. Pediatrics 138:
Kutbi, Hebah; Wehby, George L; Moreno Uribe, Lina M et al. (2016) Maternal underweight and obesity and risk of orofacial clefts in a large international consortium of population-based studies. Int J Epidemiol :
Leslie, Elizabeth J; Liu, Huan; Carlson, Jenna C et al. (2016) A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3. Am J Hum Genet 98:744-54
Tollånes, Mette C; Strandberg-Larsen, Katrine; Forthun, Ingeborg et al. (2016) Cohort profile: cerebral palsy in the Norwegian and Danish birth cohorts (MOBAND-CP). BMJ Open 6:e012777
Arendt, Linn Håkonsen; Ramlau-Hansen, Cecilia Høst; Wilcox, Allen J et al. (2016) Placental Weight and Male Genital Anomalies: A Nationwide Danish Cohort Study. Am J Epidemiol 183:1122-8
DeRoo, Lisa A; Wilcox, Allen J; Lie, Rolv T et al. (2016) Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring: a large population-based pooling study. Eur J Epidemiol 31:1021-1034
Jukic, Anne Marie Z; McConnaughey, D Robert; Weinberg, Clarice R et al. (2016) Long-term Recall of Time to Pregnancy. Epidemiology 27:705-11

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