In the mid-1980s we carried out a prospective study of early pregnancy in which we enrolled 221 health women who were planning to become pregnant. These women collected daily urine specimens for up to six months. We've assayed these specimens to describe the hormonal events of the menstrual cycle and early pregnancy. 155 women became clinically pregnant during the study, while 44 had pregnancies that ended so early that the pregnancies were detectable only by assay of urinary human chorionic gonadotropin. This unique study has been called a landmark, and continues to provide a rich resource for the description of the earliest stages of pregnancy. (More than 30,000 urine samples are still being stored.) We've published 50 papers from this study over the past two decades, some of which have led to new understanding of the fundamental processes of conception and early pregnancy. In addition, we have continued to make use of large population registries in order to pursue basic questions on pregnancy and maternal and infant health. We have worked especially closely with Norwegian colleagues in the analysis of the Norwegian Medical Birth Registry. Last year's progress. We have begun a study of events during pregnancy and the subsequent risk of cerebral palsy, based within the two national birth cohorts of Norway and Denmark. This study, in collaboration with Norwegian and Danish researchers will identify approximately 350 children with cerebral palsy whose mothers were enrolled in the two birth cohorts. This is by far the largest cohort study of cerebral palsy ever conducted, and will allow biological specimens collected during pregnancy to be used to identify exposures and early biological changes (such as inflammation) that may lead to cerebral palsy.

Project Start
Project End
Budget Start
Budget End
Support Year
35
Fiscal Year
2012
Total Cost
$520,720
Indirect Cost
City
State
Country
Zip Code
Weinberg, Clarice R; Shi, Min; Basso, Olga et al. (2017) Season of Conception, Smoking, and Preeclampsia in Norway. Environ Health Perspect 125:067022
Chin, Helen B; Baird, Donna D; McConnaughey, D Robert et al. (2017) Long-term Recall of Pregnancy-related Events. Epidemiology 28:575-579
Kutbi, Hebah; Wehby, George L; Moreno Uribe, Lina M et al. (2017) Maternal underweight and obesity and risk of orofacial clefts in a large international consortium of population-based studies. Int J Epidemiol 46:190-199
Morken, N-H; Halland, F; DeRoo, L A et al. (2017) Offspring birthweight by gestational age and parental cardiovascular mortality: a population-based cohort study. BJOG :
Kummet, Colleen M; Moreno, Lina M; Wilcox, Allen J et al. (2016) Passive Smoke Exposure as a Risk Factor for Oral Clefts-A Large International Population-Based Study. Am J Epidemiol 183:834-41
Leslie, Elizabeth J; Liu, Huan; Carlson, Jenna C et al. (2016) A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3. Am J Hum Genet 98:744-54
Forthun, Ingeborg; Wilcox, Allen J; Strandberg-Larsen, Katrine et al. (2016) Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring. Pediatrics 138:
Markunas, Christina A; Wilcox, Allen J; Xu, Zongli et al. (2016) Maternal Age at Delivery Is Associated with an Epigenetic Signature in Both Newborns and Adults. PLoS One 11:e0156361
DeRoo, Lisa A; Wilcox, Allen J; Lie, Rolv T et al. (2016) Maternal alcohol binge-drinking in the first trimester and the risk of orofacial clefts in offspring: a large population-based pooling study. Eur J Epidemiol 31:1021-1034
DeRoo, Lisa; Skjærven, Rolv; Wilcox, Allen et al. (2016) Placental abruption and long-term maternal cardiovascular disease mortality: a population-based registry study in Norway and Sweden. Eur J Epidemiol 31:501-11

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