Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. Enrolllment of the 270 children will be complete by fall, 2013.

Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2013
Total Cost
$185,118
Indirect Cost
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Chen, Aimin; Feresu, Shingairai A; Fernandez, Cristina et al. (2009) Maternal obesity and the risk of infant death in the United States. Epidemiology 20:74-81
Cao, Y A N G; Calafat, Antonia M; Doerge, Daniel R et al. (2008) Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula. J Expo Sci Environ Epidemiol :