Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. Enrolllment of the 270 children will be complete by fall, 2013.

Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2013
Total Cost
$185,118
Indirect Cost
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State
Country
Zip Code
Adgent, Margaret A; Rogan, Walter J (2015) Triclosan and prescription antibiotic exposures and enterolactone production in adults. Environ Res 142:66-71
Wang, Yan; Cupul-Uicab, Lea A; Rogan, Walter J et al. (2015) Recreational Exercise Before and During Pregnancy in Relation to Plasma C-Reactive Protein Concentrations in Pregnant Women. J Phys Act Health 12:770-5
Wang, Yan; Rogan, Walter J; Chen, Hsin-Yi et al. (2015) Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study. Int J Hyg Environ Health 218:639-44
Wang, Yan; Rogan, Walter J; Chen, Pau-Chung et al. (2014) Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study. Environ Health Perspect 122:529-34
Wang, Yan; Chen, Aimin; Dietrich, Kim N et al. (2014) Postnatal exposure to methyl mercury and neuropsychological development in 7-year-old urban inner-city children exposed to lead in the United States. Child Neuropsychol 20:527-38
Liu, Jianghong; Liu, Xianchen; Wang, Wei et al. (2014) Blood lead concentrations and children's behavioral and emotional problems: a cohort study. JAMA Pediatr 168:737-45
Council on Environmental Health; Rogan, Walter J; Paulson, Jerome A et al. (2014) Iodine deficiency, pollutant chemicals, and the thyroid: new information on an old problem. Pediatrics 133:1163-6
Adgent, Margaret A; Flake, Gordon P; Umbach, David M et al. (2013) Urogenital epithelial cells as simple markers of estrogen response in infants: methods and applications. PLoS One 8:e77061
Adgent, Margaret A; Daniels, Julie L; Rogan, Walter J et al. (2012) Early-life soy exposure and age at menarche. Paediatr Perinat Epidemiol 26:163-75
Adgent, Margaret A; Daniels, Julie L; Edwards, Lloyd J et al. (2011) Early-life soy exposure and gender-role play behavior in children. Environ Health Perspect 119:1811-6

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