Abstract

We contributed to a NTP technical report of rodent bioassays on a flame-retardant, pentabromodiphenyl ether mixture (DE-71), that was reviewed by the NTP Special Emphasis Panel in June 2015. We also participated in study design committees for over 10 chemicals that will be tested by the NTP. We published papers in the scientific literature on the biological effects chemicals that were recently tested in mice and rats by the NTP: arsenic, trimethylolpropane triacrylate and Ginkgo biloba. We continued to provide advice on statistical methods for evaluating alternative methods for NTP's toxicity and carcinogenicity testing. These include: 1) providing advice about the analysis of high throughput data from cell-based assays of chemicals selected by the NTP, that were generated by the NIH Chemical Genomics Center, and 2) providing advice about how to combine batteries of in vitro test results to predict in vivo results.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES045004-19
Application #
9143425
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Cora, Michelle C; Gwinn, William; Wilson, Ralph et al. (2017) A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice. Toxicol Pathol 45:614-623
Frawley, Rachel P; Smith, Matthew J; White Jr, Kimber L et al. (2016) Immunotoxic effects of sodium tungstate dihydrate on female B6C3F1/N mice when administered in drinking water. J Immunotoxicol 13:666-75
Willson, C J; Flake, G P; Sills, R C et al. (2016) Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats. Vet Pathol 53:682-90
Ryan, Kristen R; Cesta, Mark F; Herbert, Ronald et al. (2016) Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health :
Rider, Cynthia V; Chan, Po; Herbert, Ron A et al. (2016) Dermal Exposure to Cumene Hydroperoxide: Assessing Its Toxic Relevance and Oxidant Potential. Toxicol Pathol 44:749-62
Sanders, J Michael; Coulter, Sherry J; Knudsen, Gabriel A et al. (2016) Disruption of estrogen homeostasis as a mechanism for uterine toxicity in Wistar Han rats treated with tetrabromobisphenol A. Toxicol Appl Pharmacol 298:31-9
Catlin, Natasha R; Herbert, Ron; Janardhan, Kyathanahalli et al. (2016) Dose-response assessment of the dermal toxicity of Virginia cedarwood oil in F344/N rats and B6C3F1/N mice. Food Chem Toxicol 98:159-168
Dunnick, J K; Sanders, J M; Kissling, G E et al. (2015) Environmental chemical exposure may contribute to uterine cancer development: studies with tetrabromobisphenol A. Toxicol Pathol 43:464-73
Hong, Hue-Hua L; Hoenerhoff, Mark J; Ton, Thai-Vu et al. (2015) Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal. Toxicol Pathol 43:872-82
Rider, Cynthia V; Nyska, Abraham; Cora, Michelle C et al. (2014) Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets. Toxicol Pathol 42:830-43

Showing the most recent 10 out of 39 publications