Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this catch-all project comprises two project, described below A workshop report presents state-of-the-art assessment of endocrine disruption in neonates. We also conducted a study of determinants of age at menarche among young women in the Collaborative Perinatal Project. The main finding was that, in contrast with a previous study, that exposure to cigarette smoke in utero was unrelated to subsequent age at menarche. Two other projects on which I collaborated were lead by Dr. Donna Baird of the NIEHS Epidemiology Branch and are described in her report. Last years progress: 5 papers were published (see list below).

Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2009
Total Cost
$91,579
Indirect Cost
City
State
Country
Zip Code
Trabert, Britton; Chodick, Gabriel; Shalev, Varda et al. (2014) Gestational diabetes and the risk of cryptorchidism and hypospadias. Epidemiology 25:152-3
Jensen, Elizabeth T; Longnecker, Matthew P (2014) Pharmacologic sex hormones in pregnancy in relation to offspring obesity. Obesity (Silver Spring) 22:2406-12
Mattsson, K; Källén, K; Longnecker, M P et al. (2013) Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity. Diabetologia 56:1689-95
Jukic, Anne Marie Z; Lawlor, Debbie A; Juhl, Mette et al. (2013) Physical activity during pregnancy and language development in the offspring. Paediatr Perinat Epidemiol 27:283-93
Trabert, Britton; Longnecker, Matthew P; Graubard, Barry I et al. (2011) Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus. Cancer Causes Control 22:689-95
Eggesbø, Merete; Thomsen, Cathrine; Jørgensen, Jens V et al. (2011) Associations between brominated flame retardants in human milk and thyroid-stimulating hormone (TSH) in neonates. Environ Res 111:737-43
Baird, Donna Day; Saldana, Tina M; Nepomnaschy, Pablo A et al. (2010) Within-person variability in urinary phthalate metabolite concentrations: measurements from specimens after long-term frozen storage. J Expo Sci Environ Epidemiol 20:169-75
Basso, O; Pennell, M L; Chen, A et al. (2010) Mother's age at menarche and offspring size. Int J Obes (Lond) 34:1766-71
Ye, Xibiao; Qian, Haojun; Xu, Peicheng et al. (2009) Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings. Int J Hyg Environ Health 212:378-86
Nepomnaschy, Pablo A; Baird, Donna Day; Weinberg, Clarice R et al. (2009) Within-person variability in urinary bisphenol A concentrations: measurements from specimens after long-term frozen storage. Environ Res 109:734-7

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