Abstract

Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this catch-all project comprises one project, described below. We examined the association of gestational diabetes with subsequent risk of hypospadias and cryptorchidism in offspring born in the Collaborative Perinatal Project. No association was found, which may be because the metabolic disturbances due to gestational diabetes occur after the period of fetal development when the fetus is most susceptible to environmental influences. A report was published. We examined in utero exposure to maternal pharmacologic hormone use in pregnancy in relation to obesity in childhood. Pregnant women who took diethylstilbestrol or oral contraceptives during specific periods of pregnancy were more likely to have obese children. The findings provide general support for the """"""""obesogens"""""""" hypothesis. A report is in press.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES049021-18
Application #
8929729
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Trabert, Britton; Chodick, Gabriel; Shalev, Varda et al. (2014) Gestational diabetes and the risk of cryptorchidism and hypospadias. Epidemiology 25:152-3
Jensen, Elizabeth T; Longnecker, Matthew P (2014) Pharmacologic sex hormones in pregnancy in relation to offspring obesity. Obesity (Silver Spring) 22:2406-12
Mattsson, K; Källén, K; Longnecker, M P et al. (2013) Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity. Diabetologia 56:1689-95
Jukic, Anne Marie Z; Lawlor, Debbie A; Juhl, Mette et al. (2013) Physical activity during pregnancy and language development in the offspring. Paediatr Perinat Epidemiol 27:283-93
Trabert, Britton; Longnecker, Matthew P; Graubard, Barry I et al. (2011) Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus. Cancer Causes Control 22:689-95
Eggesbø, Merete; Thomsen, Cathrine; Jørgensen, Jens V et al. (2011) Associations between brominated flame retardants in human milk and thyroid-stimulating hormone (TSH) in neonates. Environ Res 111:737-43
Baird, Donna Day; Saldana, Tina M; Nepomnaschy, Pablo A et al. (2010) Within-person variability in urinary phthalate metabolite concentrations: measurements from specimens after long-term frozen storage. J Expo Sci Environ Epidemiol 20:169-75
Basso, O; Pennell, M L; Chen, A et al. (2010) Mother's age at menarche and offspring size. Int J Obes (Lond) 34:1766-71
Ye, Xibiao; Qian, Haojun; Xu, Peicheng et al. (2009) Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings. Int J Hyg Environ Health 212:378-86
Nepomnaschy, Pablo A; Baird, Donna Day; Weinberg, Clarice R et al. (2009) Within-person variability in urinary bisphenol A concentrations: measurements from specimens after long-term frozen storage. Environ Res 109:734-7

Showing the most recent 10 out of 12 publications