The Agricultural Health Study (AHS) is a long-term prospective study of potential health effects associated with exposure to pesticides and other agricultural exposures. The study is a collaboration of the National Cancer Institute, the National Institute of Environmental Health Sciences, and the US Environmental Protection Agency, with additional collaboration by the National Institute for Occupational Safety and Health. We are examining cancer incidence and other health endpoints in a prospective study of licensed pesticide applicators, spouses and children from North Carolina (NC) and Iowa (IA). Over a 3-year period (1993-7), we enrolled more than 57,000 licensed applicators, representing 82% of eligible private pesticide applicators (largely farmers) in IA and NC and 43% of commercial applicators from Iowa. About 40% of the private applicators also completed a more detailed take-home questionnaire covering farming practices and health. Nearly 32,000 spouses of farmer applicators enrolled and 2/3 of these also provided data on reproductive health, including information on all children under age 21. Since enrollment, 70% of participants completed the five-year followup phone interview (1999-2003) and the study is on track to achieve a similar response rate in our current followup phone interview. Annually, cancer incidence among the applicators, spouses, and children is determined through linkage with the population-based cancer registries in IA and NC. Follow-up computer-assisted telephone interviews are used to update exposure information, identify cases of non-malignant disease, and to collect information on changes in health status since enrollment in the study. We are currently completing the second round of followup with cohort members. Buccal-cell samples have been collected from participants in order to extract DNA for future analyses of gene and environment interactions. In addition, a dietary assessment (food frequency questionnaire) was self-completed and returned by mail. In-depth assessment of agricultural exposures has been done for a small sample of farmers and their families in order to validate the questionnaires and facilitate exposure classification. Both environmental and biological samples were collected. Non-cancer outcomes of particular interest in this follow-up period include neurological diseases and symptoms (Parkinson's Disease, hearing loss, depression, and neurobehavioral function), respiratory and allergic outcomes (asthma, rhinitis, chronic bronchitis, respiratory mortality), heart attacks (incidence and mortality), diabetes (both gestational and in adults), autoimmune diseases (rheumatoid arthritis), age-related macular degeneration, and reproductive outcomes (fertility, birthweight, pre-eclampsia, spontaneous abortion) in addition to cancer. We are currently involved in a number of substudies to collect more detailed information on potential health consequences of pesticides. The Growth and Puberty (GAP) Study is an intramurally-funded pilot study to assess the feasibility of measuring early puberty markers (hormone levels in urine and saliva, height velocity, Tanner staging) among farm children in the AHS. This study has enrolled approximately 60 children and the last of the three home visits will be completed by December 2008. The Genes and Age Related Macular Degeneration (GENARM) Study is obtaining medical records, opthamalogical photographs, and saliva as a source of DNA for individuals who reported incident macular degeneration at one of the followup interviews. Field work is completed and data analysis is ongoing. In a collaboration with Frederic Gerr at the University of IA, we conducted a study of neurobehavioral function using a number of standardized tests. Over 700 farmers participated and we are currently analyzing specimens for paraoxonase activity and genes related to organophosphate metabolism. Two more (Parkinson's disease and lung health) are described in separate annual reports. Recent results from the Agricultural Health Study include: 1) Significant association of allergic asthma in adults with pesticide use, particularly organophosphate insecticides which have been shown in animal models to increase allergic airway responsiveness, 2) significant association with pesticides and rhinitis among commercial pesticide applicators with a dose-response relationship for users of both 2,4-D and glyphosate (common herbicides), and 3) no association with heart attack mortality and morbidity with pesticide use. We continue to analyze data on farm exposures and non-cancer morbidity. Ongoing work focuses on allergic and respiratory outcomes, reproductive outcomes, endocrine disorders, and neurological outcomes. Rhinitis is a common symptom among farmers and has been shown to be predictive of future respiratory disease;we recently reported that several common pesticides were associated with rhinitis among both farmers and commercial applicators. Use of specific pesticides was associated with thyroid disease among farm women;we have just started the analysis of thyroid disease in men. Recent work also focuses on mortality in the cohort, indicating elevated injury mortality common among farmers, but also increased risk of specific cancer mortality;we are currently conducting an analysis of risk factors for injury mortality among farmers. We are focusing on chronic diseases of aging including stroke, kidney disease, diabetes, and myocardial infarction. Follow-up telephone interviews were completed in February 2010. We are currently conducting validation studies of self-reported ALS and macular degeneration and are planning for validation of self-reported disease outcomes for Parkinson's disease, stroke, and rheumatoid arthritis. With the newly collected data, we plan to conduct analysis of incident diseases such as asthma to expand on our earlier cross-sectional results.

Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2010
Total Cost
$273,172
Indirect Cost
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Lerro, Catherine C; Andreotti, Gabriella; Koutros, Stella et al. (2018) Alachlor Use and Cancer Incidence in the Agricultural Health Study: An Updated Analysis. J Natl Cancer Inst :
Shrestha, Srishti; Parks, Christine G; Goldner, Whitney S et al. (2018) Incident thyroid disease in female spouses of private pesticide applicators. Environ Int 118:282-292
Lerro, Catherine C; Beane Freeman, Laura E; DellaValle, Curt T et al. (2018) Occupational pesticide exposure and subclinical hypothyroidism among male pesticide applicators. Occup Environ Med 75:79-89
Wyss, Annah B; House, John S; Hoppin, Jane A et al. (2018) Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study. Thorax 73:279-282
Andreotti, Gabriella; Koutros, Stella; Hofmann, Jonathan N et al. (2018) Glyphosate Use and Cancer Incidence in the Agricultural Health Study. J Natl Cancer Inst 110:509-516
Baumert, Brittney O; Carnes, Megan Ulmer; Hoppin, Jane A et al. (2018) Sleep apnea and pesticide exposure in a study of US farmers. Sleep Health 4:20-26
Gaudet, Mia M; Carter, Brian D; Brinton, Louise A et al. (2017) Pooled analysis of active cigarette smoking and invasive breast cancer risk in 14 cohort studies. Int J Epidemiol 46:881-893
Engel, Lawrence S; Werder, Emily; Satagopan, Jaya et al. (2017) Insecticide Use and Breast Cancer Risk among Farmers' Wives in the Agricultural Health Study. Environ Health Perspect 125:097002
Rinsky, Jessica L; Richardson, David B; Wing, Steve et al. (2017) Assessing the Potential for Bias From Nonresponse to a Study Follow-up Interview: An Example From the Agricultural Health Study. Am J Epidemiol 186:395-404
Louis, Lydia M; Lerro, Catherine C; Friesen, Melissa C et al. (2017) A prospective study of cancer risk among Agricultural Health Study farm spouses associated with personal use of organochlorine insecticides. Environ Health 16:95

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