The overall goal of the this project is to understand how cells and tissues respond to environmental stress. Glucocorticoids are primary stress response hormones and chronic evaluation of glucocorticoids due to prolonged stress and/or chronic therapeutic intervention can lead to detrimental actions on human health. Thus studying their actions and signaling pathways is critical to the mission of NIEHS. We seek to understand how glucocorticoids signal in a cell specific manner. These hormones regulate multiple aspects of physiology including glucose homeostasis, protein metabolism, skeletal growth, connective tissue metabolism, respiratory function, immune surveillance and components of human behavior. They are essential for life in man.

Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
2013
Total Cost
$2,459,557
Indirect Cost
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State
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Quinn, Matthew A; Cidlowski, John A (2016) Endogenous hepatic glucocorticoid receptor signaling coordinates sex-biased inflammatory gene expression. FASEB J 30:971-82
Regan Anderson, Tarah M; Ma, Shi Hong; Raj, Ganesh V et al. (2016) Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res 76:1653-63
Cruz-Topete, Diana; Myers, Page H; Foley, Julie F et al. (2016) Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice. Endocrinology 157:2759-71
He, Bo; Cruz-Topete, Diana; Oakley, Robert H et al. (2016) Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver. Mol Cell Biol 36:714-30
Cain, Derek W; Cidlowski, John A (2015) Specificity and sensitivity of glucocorticoid signaling in health and disease. Best Pract Res Clin Endocrinol Metab 29:545-56
Whirledge, Shannon D; Oakley, Robert H; Myers, Page H et al. (2015) Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization. Proc Natl Acad Sci U S A 112:15166-71
Whirledge, Shannon; Senbanjo, Linda T; Cidlowski, John A (2015) Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80-7
Oakley, Robert H; Cidlowski, John A (2015) Glucocorticoid signaling in the heart: A cardiomyocyte perspective. J Steroid Biochem Mol Biol 153:27-34
Deak, Terrence; Quinn, Matt; Cidlowski, John A et al. (2015) Neuroimmune mechanisms of stress: sex differences, developmental plasticity, and implications for pharmacotherapy of stress-related disease. Stress 18:367-80
Bortner, Carl D; Cidlowski, John A (2014) Ion channels and apoptosis in cancer. Philos Trans R Soc Lond B Biol Sci 369:20130104

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