The goal of this project is to define how basic cellular mechanisms suppress, activate and execute the process of apoptosis or programmed cell death. Apoptosis is a fundamental component of virtually all aspects of biology, being critical for both developmental and cellular homeostasis in all multi-cellular organisms. Extensive studies worldwide have now implicated either excess or impaired apoptosis in numerous human diseases including cancer, AIDS, autoimmune diseases, sepsis, as well as toxic responses to environmental agents. Additionally, many of the therapies used for the treatment of cancer work by the activation of inherent cellular apoptotic programs.

Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
2012
Total Cost
$864,834
Indirect Cost
City
State
Country
Zip Code
Whirledge, Shannon D; Jewell, Christine M; Barber, Lisa M et al. (2017) Generating diversity in human glucocorticoid signaling through a racially diverse polymorphism in the beta isoform of the glucocorticoid receptor. Lab Invest 97:1282-1295
Whirledge, Shannon; Cidlowski, John A (2017) Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction. Trends Endocrinol Metab 28:399-415
Busada, Jonathan T; Cidlowski, John A (2017) Mechanisms of Glucocorticoid Action During Development. Curr Top Dev Biol 125:147-170
Oakley, Robert H; Busillo, John M; Cidlowski, John A (2017) Cross-talk between the glucocorticoid receptor and MyoD family inhibitor domain-containing protein provides a new mechanism for generating tissue-specific responses to glucocorticoids. J Biol Chem 292:5825-5844
Cain, Derek W; Cidlowski, John A (2017) Immune regulation by glucocorticoids. Nat Rev Immunol 17:233-247
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Quinn, Matthew A; Cidlowski, John A (2016) Endogenous hepatic glucocorticoid receptor signaling coordinates sex-biased inflammatory gene expression. FASEB J 30:971-82
He, Bo; Cruz-Topete, Diana; Oakley, Robert H et al. (2016) Human Glucocorticoid Receptor ? Regulates Gluconeogenesis and Inflammation in Mouse Liver. Mol Cell Biol 36:714-30
Cruz-Topete, Diana; He, Bo; Xu, Xiaojiang et al. (2016) Kr├╝ppel-Like Factor 13 is a major mediator of Glucocorticoid Receptor-Signaling in Cardiomyocytes and protects these Cells from DNA Damage and Death. J Biol Chem :

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