Anesthetics and analgesics are important components of an animal research program. It is required by law and it is our ethical responsibility to avoid and minimize pain and distress in animals undergoing research. NIEHS has a strong rodent surgery core that provides surgical services to those investigators whose research requires rodent surgery. It is important for adequate and complete anesthesia and analgesia be provided for the animal's well-being;however it is also important that the selection of the anesthetic or analgesic not interfere with the research goal. The research in ES102825-01 investigates the efficacy, safety, duration of effect, and reliability of various types of anesthetics and analgesics. This research broadens our understanding of anesthetics and analgesics in mice and rats-ensuring adequate pain relief without interfering with the principle animal users research. We evaluate commercially available veterinary products as well as investigating new ways of compounding analagesics for longer duration of action. Recently we have been investigating the use of pluronic gel in providing a sustained release buprenorphine compound

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2013
Total Cost
$203,827
Indirect Cost
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State
Country
Zip Code
Blankenship-Paris, Terry L; Dutton, John W; Goulding, David R et al. (2016) Evaluation of buprenorphine hydrochloride Pluronic(®) gel formulation in male C57BL/6NCrl mice. Lab Anim (NY) 45:370-9
Tubbs, Jacquelyn T; Kissling, Grace E; Travlos, Greg S et al. (2011) Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice. J Am Assoc Lab Anim Sci 50:185-91
Zegre Cannon, Coralie; Kissling, Grace E; Goulding, David R et al. (2011) Analgesic effects of tramadol, carprofen or multimodal analgesia in rats undergoing ventral laparotomy. Lab Anim (NY) 40:85-93
Goulding, David R; Myers, Page H; Goulding, Eugenia H et al. (2010) The effects of perioperative analgesia on litter size in Crl:CD1(ICR) mice undergoing embryo transfer. J Am Assoc Lab Anim Sci 49:423-6
Cannon, Coralie Zegre; Kissling, Grace E; Hoenerhoff, Mark J et al. (2010) Evaluation of dosages and routes of administration of tramadol analgesia in rats using hot-plate and tail-flick tests. Lab Anim (NY) 39:342-51