We have recently guided the data analysis for several projects, primarily involving data from the Agricultural Health Study (AHS), a cohort of licensed pesticide applicators (mostly farmers) from Iowa and North Carolina. One project probed a possible relationship between pesticide exposure and depression among male private applicators in the AHS. We used inverse probability weighting to account for exclusions due to missing data and polytomous logistic regression to estimate odds ratios. Ever use of fumigants as a class and several individual pesticides were associated with depression. In light of the growing evidence that suggests that pesticide use contributes to respiratory symptoms, we are using data from the AHS to evaluate the association of 79 currently used pesticides with two types of wheeze: allergic wheeze and non-allergic wheeze. Allergic wheeze required self-report of one or more episodes of wheeze during the past year plus history of doctor-diagnosed hay fever; non-allergic wheeze required the wheeze symptom but without history of hay fever. We used polytomous logistic regression to compare those with each of the two types of wheeze to controls (those without wheeze symptoms). Of the 79 pesticides studied, with exposure assessed dichotomously (current use or not), 20 were associated with non-allergic wheeze (18 positively, 2 negatively) and 17 were associated with allergic wheeze (16 positively, 1 negatively) with ten pesticides common to both types of wheeze. Investigation of other aspects of the epidemiology of respiratory disease and symptoms in relationship to farming exposures, including pesticides, is continuing.
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| Lee, Mi Kyeong; Carnes, Megan U; Butz, Natasha et al. (2018) Exposures Related to House Dust Microbiota in a U.S. Farming Population. Environ Health Perspect 126:067001 |
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| Wyss, Annah B; House, John S; Hoppin, Jane A et al. (2018) Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study. Thorax 73:279-282 |
| Baumert, Brittney O; Carnes, Megan Ulmer; Hoppin, Jane A et al. (2018) Sleep apnea and pesticide exposure in a study of US farmers. Sleep Health 4:20-26 |
| Li, Yuanyuan; Umbach, David M; Li, Leping (2017) Putative genomic characteristics of BRAF V600K versus V600E cutaneous melanoma. Melanoma Res 27:527-535 |
| Hoppin, Jane A; Umbach, David M; Long, Stuart et al. (2017) Pesticides are Associated with Allergic and Non-Allergic Wheeze among Male Farmers. Environ Health Perspect 125:535-543 |
| Beard, John D; Engel, Lawrence S; Richardson, David B et al. (2017) Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis survival. PLoS One 12:e0185751 |
| House, John S; Wyss, Annah B; Hoppin, Jane A et al. (2017) Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study. J Allergy Clin Immunol 140:249-256.e14 |
| Carnes, Megan Ulmer; Hoppin, Jane A; Metwali, Nervana et al. (2017) House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population. Ann Am Thorac Soc 14:324-331 |
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