The goal of this project is to develop improved methods for the diagnosis and treatment of ocular inflammatory diseases (both infectious and non-infectious) in patients of all ages including uveitis, scleritis, inflammatory diseases of the ocular surface, and intraocular malignancies. This protocol allows for hypothesis generating research, clinical training of fellows yusing cutting edge diagnostic an dtherapeutic approaches for uveitis (as well as standrad of care) and masquerade syndromes. Currently, exosomes and other biomarkers as well as epigenetic modification are the focus. Additionally, the heterogeneity of primary outcome measures uses in uveitic clinical trials presents practical challenges and outcomes development reserach is also actively carried out under this protocol.
| Kim, Jane S; Jaworski, Laurence; Patel-Donnelly, Dipti et al. (2017) WALDENSTRÖM'S MACROGLOBULINEMIA MASQUERADING AS BIRDSHOT CHORIORETINOPATHY. Retin Cases Brief Rep 11:152-155 |
| Knickelbein, Jared E; Sen, H Nida (2016) Multimodal Imaging of the White Dot Syndromes and Related Diseases. J Clin Exp Ophthalmol 7: |
| Kim, Jane S; Knickelbein, Jared E; Jaworski, Laurence et al. (2016) Enhanced Depth Imaging Optical Coherence Tomography in Uveitis: An Intravisit and Interobserver Reproducibility Study. Am J Ophthalmol 164:49-56 |
| Chen, Ping; Tucker, William; Hannes, Susan et al. (2015) Levels of blood CD1c+ mDC1 and CD1chi mDC1 subpopulation reflect disease activity in noninfectious uveitis. Invest Ophthalmol Vis Sci 56:346-52 |
| Kim, Jane S; Knickelbein, Jared E; Nussenblatt, Robert B et al. (2015) Clinical trials in noninfectious uveitis. Int Ophthalmol Clin 55:79-110 |
| Knickelbein, Jared E; Chan, Chi-Chao; Sen, H Nida et al. (2015) Inflammatory Mechanisms of Age-related Macular Degeneration. Int Ophthalmol Clin 55:63-78 |
| Liu, Baoying; Dhanda, Ashwin; Hirani, Sima et al. (2015) CD14++CD16+ Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses. J Immunol 194:5150-60 |
| Levin, Marc H; Pistilli, Maxwell; Daniel, Ebenezer et al. (2014) Incidence of visual improvement in uveitis cases with visual impairment caused by macular edema. Ophthalmology 121:588-95.e1 |
| Artornsombudh, Pichaporn; Pistilli, Maxwell; Foster, C Stephen et al. (2014) Factors predictive of remission of new-onset anterior uveitis. Ophthalmology 121:778-84 |
| Sen, H Nida; Vitale, Susan; Gangaputra, Sapna S et al. (2014) Periocular corticosteroid injections in uveitis: effects and complications. Ophthalmology 121:2275-86 |
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