Abstract

In the AGES cohort we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs of disease in other organ systems, including the brain. A detailed follow-up examination on a subset of surviving elderly individuals in this cohort occurred between 2008 and 2011;data to be ready for analysis in Fall 2012. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. DNA on a subgroup of the AGES participants was genotyped in 2009 using an Illumina 370CNV BeadChip array. Exome chip genotyping will become available in Fall 2012. For more information on the AGES study, see www.hjarta.is/english/ages. Refer to project bibliography on the study website for published papers and papers in press. See also annual reports ZIAAG007380 and ZIAG006000(Dr. Harris).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000401-11
Application #
8556825
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2012
Total Cost
$328,736
Indirect Cost

  Institution

Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Xu, Kaipin; Sigurdsson, Sigurdur; Gudnason, Vilmundur et al. (2018) Reliable quantification of marrow fat content and unsaturation level using in vivo MR spectroscopy. Magn Reson Med 79:1722-1729
Qiu, Chengxuan; Ding, Jie; Sigurdsson, Sigurdur et al. (2018) Differential associations between retinal signs and CMBs by location: The AGES-Reykjavik Study. Neurology 90:e142-e148
Sobrin, Lucia; Chong, Yong He; Fan, Qiao et al. (2017) Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes 66:3130-3141
Gaksch, Martin; Jorde, Rolf; Grimnes, Guri et al. (2017) Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLoS One 12:e0170791
Thordardottir, Marianna; Lindqvist, Ebba K; Lund, Sigrun H et al. (2017) Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study. Blood Adv 1:2186-2192
Telomeres Mendelian Randomization Collaboration; Haycock, Philip C; Burgess, Stephen et al. (2017) Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol 3:636-651
Chu, Audrey Y; Deng, Xuan; Fisher, Virginia A et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet 49:125-130
Thorsteinsdottir, Sigrun; Lund, Sigrun H; Lindqvist, Ebba K et al. (2017) Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study. Blood Adv 1:2790-2798
Cashman, Kevin D; Dowling, Kirsten G; Škrabáková, Zuzana et al. (2016) Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 103:1033-44
Jensen, Richard A; Sim, Xueling; Smith, Albert Vernon et al. (2016) Novel Genetic Loci Associated With Retinal Microvascular Diameter. Circ Cardiovasc Genet 9:45-54

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