Abstract

The MESA study is on-going. MESA study visit five began in April 2010. Analyses of various ocular phenotypes, including retinal microvascular disease, have resulted in multiple published manuscripts with more in press, or under preparation. Genotype and phenotype data began to be released on dbGaP in the first quarter of 2010. Results from genome-wide analyses are just beginning to become available and will be a focus of future efforts. The MESA Study has several ancillary studies, including a lung component (funded by NHLBI) and an air pollution component (funded by the EPA). Discussions to integrate and analyze data across various study components have resulted in several paper proposals with manuscripts in process. More information about the MESA Study and its ancillary studies, including a full list of participating investigators and institutions and a complete list of publications to-date, can be found at www.mesa-nhlbi.org.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000403-09
Application #
8149162
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2010
Total Cost
$156,082
Indirect Cost

  Institution

Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Fernandez, Antonio B; Ballard, Kevin D; Wong, Tien Y et al. (2018) Age-related macular degeneration and progression of coronary artery calcium: The Multi-Ethnic Study of Atherosclerosis. PLoS One 13:e0201000
Sobrin, Lucia; Chong, Yong He; Fan, Qiao et al. (2017) Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes 66:3130-3141
Xie, Jing; Ikram, M Kamran; Cotch, Mary Frances et al. (2017) Association of Diabetic Macular Edema and Proliferative Diabetic Retinopathy With Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Ophthalmol 135:586-593
Telomeres Mendelian Randomization Collaboration; Haycock, Philip C; Burgess, Stephen et al. (2017) Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol 3:636-651
Cotch, Mary Frances (2016) Public Health Surveillance-The Integral Role of Community-Based Studies. JAMA Ophthalmol :
Jensen, Richard A; Sim, Xueling; Smith, Albert Vernon et al. (2016) Novel Genetic Loci Associated With Retinal Microvascular Diameter. Circ Cardiovasc Genet 9:45-54
Chew, Merwyn; Xie, Jing; Klein, Ronald et al. (2016) Sleep apnea and retinal signs in cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Sleep Breath 20:15-23
Fan, Qiao; Verhoeven, Virginie J M; Wojciechowski, Robert et al. (2016) Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nat Commun 7:11008
Fisher, Diana E; Klein, Barbara E K; Wong, Tien Y et al. (2016) Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis. Ophthalmology 123:1297-308
Lin, Gen-Min; Redline, Susan; Klein, Ronald et al. (2016) Sex-Specific Association of Obstructive Sleep Apnea With Retinal Microvascular Signs: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 5:

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