The MESA study is on-going. MESA study visit five began in April 2010 and was completed in early 2012. Participants are being followed for health events. Analyses of various ocular phenotypes, including retinal microvascular disease, have resulted in multiple published manuscripts with more in press, or under preparation. Genotype and ocular phenotype data began to be released on dbGaP in August 2010. Genetic analyses under the auspices of MESA SHARe, CHARGE, and the BioProject are on-going. The MESA Study has numerous ancillary studies, including a lung component (funded by NHLBI) and an air pollution component (funded by the EPA). Discussions to integrate and analyze data across various study components have resulted in peer-reviewed papers and numerous multi-disciplinary collaborations, many of which are novel. More information about the MESA Study and its ancillary studies, including a full list of participating investigators and institutions and a complete, up-to-date list of publications, can be found at www.mesa-nhlbi.org. For information on how to access MESA data, refer to dbGaP (www.ncbi.nlm.nih.gov/gap).

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000403-12
Application #
8737629
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2013
Total Cost
$82,737
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Ding, Jie; Wai, Khin Lay; McGeechan, Kevin et al. (2014) Retinal vascular caliber and the development of hypertension: a meta-analysis of individual participant data. J Hypertens 32:207-15
Chong, Elaine W; Guymer, Robyn H; Klein, Ronald et al. (2014) Is renal function associated with early age-related macular degeneration? Optom Vis Sci 91:860-4
Klein, Ronald; Li, Xiaohui; Kuo, Jane Z et al. (2013) Associations of candidate genes to age-related macular degeneration among racial/ethnic groups in the multi-ethnic study of atherosclerosis. Am J Ophthalmol 156:1010-1020.e1
Stambolian, Dwight; Wojciechowski, Robert; Oexle, Konrad et al. (2013) Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error. Hum Mol Genet 22:2754-64
Sim, Xueling; Jensen, Richard A; Ikram, M Kamran et al. (2013) Genetic loci for retinal arteriolar microcirculation. PLoS One 8:e65804
Pan, Chen-Wei; Klein, Barbara E K; Cotch, Mary Frances et al. (2013) Racial variations in the prevalence of refractive errors in the United States: the multi-ethnic study of atherosclerosis. Am J Ophthalmol 155:1129-1138.e1
Jensen, Richard A; Sim, Xueling; Li, Xiaohui et al. (2013) Genome-wide association study of retinopathy in individuals without diabetes. PLoS One 8:e54232
Yau, Joanne Wen Yee; Xie, Jing; Lamoureux, Ecosse et al. (2012) Retinal microvascular calibre and risk of incident diabetes: the multi-ethnic study of atherosclerosis. Diabetes Res Clin Pract 95:265-74
Fernandez, Antonio B; Wong, Tien Y; Klein, Ronald et al. (2012) Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology 119:765-70
Yau, Joanne Wen Yee; Xie, Jing; Kawasaki, Ryo et al. (2011) Retinal arteriolar narrowing and subsequent development of CKD Stage 3: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 58:39-46

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