The MESA study is on-going. MESA study visit five began in April 2010 and was completed in early 2012. Participants are being followed for health events. Analyses of various ocular phenotypes, including retinal microvascular disease, have resulted in multiple published manuscripts with more in press, or under preparation. Genotype and ocular phenotype data began to be released on dbGaP in August 2010. Genetic analyses under the auspices of MESA SHARe, CHARGE, and the BioProject are on-going. The MESA Study has numerous ancillary studies, including a lung component (funded by NHLBI) and an air pollution component (funded by the EPA). Discussions to integrate and analyze data across various study components have resulted in peer-reviewed papers and numerous multi-disciplinary collaborations, many of which are novel. More information about the MESA Study and its ancillary studies, including a full list of participating investigators and institutions and a complete, up-to-date list of publications, can be found at www.mesa-nhlbi.org. For information on how to access MESA data, refer to dbGaP (www.ncbi.nlm.nih.gov/gap).

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000403-12
Application #
8737629
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2013
Total Cost
$82,737
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Xie, Jing; Ikram, M Kamran; Cotch, Mary Frances et al. (2017) Association of Diabetic Macular Edema and Proliferative Diabetic Retinopathy With Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Ophthalmol 135:586-593
Telomeres Mendelian Randomization Collaboration; Haycock, Philip C; Burgess, Stephen et al. (2017) Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol 3:636-651
Jensen, Richard A; Sim, Xueling; Smith, Albert Vernon et al. (2016) Novel Genetic Loci Associated With Retinal Microvascular Diameter. Circ Cardiovasc Genet 9:45-54
Cotch, Mary Frances (2016) Public Health Surveillance-The Integral Role of Community-Based Studies. JAMA Ophthalmol :
Chew, Merwyn; Xie, Jing; Klein, Ronald et al. (2016) Sleep apnea and retinal signs in cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Sleep Breath 20:15-23
Lin, Gen-Min; Redline, Susan; Klein, Ronald et al. (2016) Sex-Specific Association of Obstructive Sleep Apnea With Retinal Microvascular Signs: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 5:
Fan, Qiao; Verhoeven, Virginie J M; Wojciechowski, Robert et al. (2016) Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nat Commun 7:11008
Fisher, Diana E; Klein, Barbara E K; Wong, Tien Y et al. (2016) Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis. Ophthalmology 123:1297-308
Tandon, Arti; Chen, Ching J; Penman, Alan et al. (2015) African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans. Invest Ophthalmol Vis Sci 56:3999-4005
Fisher, Diana E; Shrager, Sandi; Shea, Steven J et al. (2015) Visual Impairment in White, Chinese, Black, and Hispanic Participants from the Multi-Ethnic Study of Atherosclerosis Cohort. Ophthalmic Epidemiol 22:321-32

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