One-hundred and five participants previously enrolled at the Clinical Center for AREDS will be followed on an annual basis for five years. These annual visits will include a comprehensive eye exam, fundus and lens photographs and a blood sample. In addition, clinical coordinators will conduct semi-annual phone calls to the participants. These follow-up visits will provide data on a cohort of participants for whom we will have the very unusual ability to report on the 15-18 year natural history of two diseases, cataract and AMD. It will also provide additional data on possible adverse effects associated with the treatment with AREDS supplements (high doses of vitamins C, E, beta-carotene, zinc and copper). There are individual case reports in the literature on the progression of AMD over a 15-year period, and population data on follow-up of cohorts of participants for 10 years, but to our knowledge no systematic data have been collected over a 15-year period. The population based data demonstrate a clear increase in the risk of AMD progression after age 80. The ability to follow this progression of disease over a very long period with serial photos will allow us to better develop hypotheses as to why some persons progress while others do not. Study Objectives The objective of this study is to follow 105 former AREDS participants annually for 5 years with a semi-annual telephone contact to collect additional data on AMD and cataracts. These follow-up visits will allow the NEI to collect additional data on possible ocular events for both AMD and cataracts and for documentation of any adverse effects associated with the AREDS treatment. Most importantly, this very long follow-up with careful photographic documentation of the progress of both cataract and AMD will allow for the development of hypotheses as to why some persons progress while others do not.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000489-04
Application #
8556855
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2012
Total Cost
$24,351
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Ding, Ying; Liu, Yi; Yan, Qi et al. (2017) Bivariate Analysis of Age-Related Macular Degeneration Progression Using Genetic Risk Scores. Genetics 206:119-133
Das, Sayantan; Forer, Lukas; Schönherr, Sebastian et al. (2016) Next-generation genotype imputation service and methods. Nat Genet 48:1284-1287
Chew, Emily Y; Launer, Lenore; Bernstein, Paul (2016) Oral Nutrient Supplementation and Cognitive Function--Reply. JAMA 315:516-7
Gardner, Thomas W; Chew, Emily Y (2016) Future opportunities in diabetic retinopathy research. Curr Opin Endocrinol Diabetes Obes 23:91-6
Popp, Nicholas A; Agrón, Elvira; Hageman, Gregory S et al. (2016) No Sex Differences in the Frequencies of Common Single Nucleotide Polymorphisms Associated with Age-Related Macular Degeneration. Curr Eye Res :1-6
Kurihara, Toshihide; Westenskow, Peter D; Gantner, Marin L et al. (2016) Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration. Elife 5:
Fritsche, Lars G; Igl, Wilmar; Bailey, Jessica N Cooke et al. (2016) A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet 48:134-43
Domalpally, Amitha; Danis, Ronald; Agrón, Elvira et al. (2016) Evaluation of Geographic Atrophy from Color Photographs and Fundus Autofluorescence Images: Age-Related Eye Disease Study 2 Report Number 11. Ophthalmology 123:2401-2407
Vitale, Susan; Clemons, Traci E; Agrón, Elvira et al. (2016) Evaluating the Validity of the Age-Related Eye Disease Study Grading Scale for Age-Related Macular Degeneration: AREDS2 Report 10. JAMA Ophthalmol 134:1041-7
Folgar, Francisco A; Yuan, Eric L; Sevilla, Monica B et al. (2016) Drusen Volume and Retinal Pigment Epithelium Abnormal Thinning Volume Predict 2-Year Progression of Age-Related Macular Degeneration. Ophthalmology 123:39-50.e1

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