This is a genetic association study evaluating whether single nucleotide polymorphisms (SNPs) in vascular endothelial growth facotr (VEGF),erythropoietin (EPO), endothelin-1 (EDN1) and activated glycation end products (AGE) genes affect the development and progression of DME. All participants will provide a blood sample, undergo an eye examination, optical coherence tomography (OCT) and potentially fluorescein angiography (FA). They will also discuss their medical, family and social history. Case participants with DME and control participants without DME will be allowed to continue receiving conventional eye treatment at the NEI under this protocol. The primary outcome variable is the genotype frequency of SNPs in the above specific genes of DME and control participants. Secondary outcomes are serum levels of VEGF, EPO, EDN1, AGE and ophthalmic measurements (visual acuity and imaging results such as FA and OCT results). Additionally, longitudinal data about response to treatment of diabetic macular edema will be gathered to attempt to discern a genetic predictor of response to particular treatment. This protocol has been terminated.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000497-04
Application #
8737661
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2013
Total Cost
$96,921
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Nicholson, Benjamin; Noble, Jason; Forooghian, Farzin et al. (2013) Central serous chorioretinopathy: update on pathophysiology and treatment. Surv Ophthalmol 58:103-26
Ardeljan, Daniel; Meyerle, Catherine B; Agron, Elvira et al. (2013) Influence of TIMP3/SYN3 polymorphisms on the phenotypic presentation of age-related macular degeneration. Eur J Hum Genet :
Dalal, Monica; Jacobs-El, Naima; Nicholson, Benjamin et al. (2013) Subconjunctival Palomid 529 in the treatment of neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 251:2705-9