Abstract

The overarching goals of the NICHD Fetal Growth Studies are to 1) determine optimal growth standards for 4 racial/ethnic groups of fetuses and 2) to identify factors associated with decrements in expected fetal growth. Related goals are in developing algorithms for better estimating fetal weight and in determining the optimal timing of delivery. A major accomplishment was in the development of a database for the storage of 2D and 3D ultrasonology images and accompanying biometric data. This database is a valuable resource for follow on work aimed at determining specific growth dimensions such as bone length, volumes or organ size. This study will determine if race-ethnic standards are needed for assessing the appropriateness of fetal growth, established growth velocities for singleton fetuses, establish trajectories for fetal growth among twin pregnancies, and establish standards for fetal growth for obese pregnant women among other research questions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHD008852-08
Application #
9150143
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst/Child Hlth/Human Dev
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Workalemahu, Tsegaselassie; Grantz, Katherine L; Grewal, Jagteshwar et al. (2018) Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy. Sci Rep 8:7274
Elmi, Angelo F; Grantz, Katherine L; Albert, Paul S (2018) An approximate joint model for multiple paired longitudinal outcomes and time-to-event data. Biometrics 74:1112-1119
Ortega-Villa, Ana Maria; Grantz, Katherine L; Albert, Paul S (2018) Estimating onset time from longitudinal and cross-sectional data with an application to estimating gestational age from longitudinal maternal anthropometry during pregnancy and neonatal anthropometry at birth. J R Stat Soc Ser A Stat Soc 181:825-842
Bao, Wei; Dar, Sharon; Zhu, Yeyi et al. (2018) Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study. J Diabetes 10:487-495
Rawal, Shristi; Tsai, Michael Y; Hinkle, Stefanie N et al. (2018) A Longitudinal Study of Thyroid Markers Across Pregnancy and the Risk of Gestational Diabetes. J Clin Endocrinol Metab 103:2447-2456
Zhu, Yeyi; Tsai, Michael Y; Sun, Qi et al. (2018) A prospective and longitudinal study of plasma phospholipid saturated fatty acid profile in relation to cardiometabolic biomarkers and the risk of gestational diabetes. Am J Clin Nutr 107:1017-1026
Hinkle, Stefanie N; Tsai, Michael Y; Rawal, Shristi et al. (2018) HbA1c Measured in the First Trimester of Pregnancy and the Association with Gestational Diabetes. Sci Rep 8:12249
Zhang, Cuilin; Hediger, Mary L; Albert, Paul S et al. (2018) Association of Maternal Obesity With Longitudinal Ultrasonographic Measures of Fetal Growth: Findings From the NICHD Fetal Growth Studies-Singletons. JAMA Pediatr 172:24-31
Grantz, Katherine L; Hediger, Mary L; Liu, Danping et al. (2018) Fetal growth standards: the NICHD fetal growth study approach in context with INTERGROWTH-21st and the World Health Organization Multicentre Growth Reference Study. Am J Obstet Gynecol 218:S641-S655.e28
Pugh, S J; Ortega-Villa, A M; Grobman, W et al. (2018) Estimating gestational age at birth from fundal height and additional anthropometrics: a prospective cohort study. BJOG 125:1397-1404

Showing the most recent 10 out of 21 publications