In the past year investigators and staff on this project developed nonparametric sequential methods for evaluation of diagnostic biomarkers. They investigated a two-stage procedures for selecting the best diagnostic biomarkers to control the probability of incorrect selection. Methods for point and interval estimation of accuracies of a binary diagnostic biomarkers were developed following group sequential evaluation of the biomarkers'sensitivity and specificity. For biomarkers whose measurements are subject to limits of detection, the group developed maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection. To design comparative diagnostic accuracy studies an adaptive approach was developed to maintain the study power due to misspecifications of nuisance parameters.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2013
Total Cost
$66,307
Indirect Cost
City
State
Country
Zip Code
Nansel, Tonja R; Lipsky, Leah M; Liu, Aiyi (2016) Greater diet quality is associated with more optimal glycemic control in a longitudinal study of youth with type 1 diabetes. Am J Clin Nutr 104:81-7
Li, Shanshan; Zhu, Yeyi; Chavarro, Jorge E et al. (2016) Healthful Dietary Patterns and the Risk of Hypertension Among Women With a History of Gestational Diabetes Mellitus: A Prospective Cohort Study. Hypertension 67:1157-65
Boghossian, Nansi S; Sicko, Robert J; Kay, Denise M et al. (2016) Rare copy number variants implicated in posterior urethral valves. Am J Med Genet A 170:622-33
Cai, Xiaoyu; Li, Huiyun; Liu, Aiyi (2016) A marginal rank-based inverse normal transformation approach to comparing multiple clinical trial endpoints. Stat Med 35:3259-71
Lipsky, Leah M; Gee, Benjamin; Liu, Aiyi et al. (2016) Glycemic control and variability in association with body mass index and body composition over 18months in youth with type 1 diabetes. Diabetes Res Clin Pract 120:97-103
Wu, Mixia; Zhang, Dianchen; Liu, Aiyi (2016) Estimation of an Accuracy Index of a Diagnostic Biomarker When the Reference Biomarker Is Continuous and Measured with Error. J Biopharm Stat :
Wu, Mixia; Shu, Yu; Li, Zhaohai et al. (2016) Repeated significance tests of linear combinations of sensitivity and specificity of a diagnostic biomarker. Stat Med 35:3397-412
Zhu, Yeyi; Olsen, Sjurdur F; Mendola, Pauline et al. (2016) Growth and obesity through the first 7 y of life in association with levels of maternal glycemia during pregnancy: a prospective cohort study. Am J Clin Nutr 103:794-800
Liu, Aiyi; Yue, Lilly Q (2016) A Conversation with Dr. Greg Campbell. J Biopharm Stat :
Rigler, Shannon L; Kay, Denise M; Sicko, Robert J et al. (2015) Novel copy-number variants in a population-based investigation of classic heterotaxy. Genet Med 17:348-57

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