Gestational diabetes is a common pregnancy complication. Although the precise underlying mechanism has yet to be identified, insulin resistance and inadequate insulin secretion to compensate for it play a central role in the pathophysiology of GDM. Excess adiposity is an important modifiable risk factor for the development of the condition. Mechanisms linking excess adiposity to elevated risk of GDM are not completely understood, but recent evidence points to the crucial role of specific hormones and cytokines (adipokines) secreted by the adipose tissue. The general goal of this project is to longitudinally collect biological specimens for research on the pathogenesis of GDM. Under this research theme, the specific aim of this project is to prospectively investigate novel biochemical markers, for instance, biomarkers involved in adipocyte cytokine secretion and metabolism in association with subsequent risk of GDM. The researchers will longitudinally collect multiple bio-specimens throughout pregnancy from more than 3,000 pregnant women enrolled in ongoing prospective studies of pregnant women. In the past year, we actively worked with the UMN laboratory to obtain data inlcuding non-targeted metabolomics data from UC Davis. We are teaming with biostatiticians analyzing the unique data we received so far.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2013
Total Cost
$116,037
Indirect Cost
City
State
Country
Zip Code
Zhu, Yeyi; Mendola, Pauline; Albert, Paul S et al. (2016) Insulin-like growth factor axis and gestational diabetes: A longitudinal study in a multiracial cohort. Diabetes :
Bao, Wei; Baecker, Aileen; Song, Yiqing et al. (2015) Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: A systematic review. Metabolism 64:756-64
Zhang, Cuilin; Sundaram, Rajeshwari; Maisog, José et al. (2015) A prospective study of prepregnancy serum concentrations of perfluorochemicals and the risk of gestational diabetes. Fertil Steril 103:184-9
Yeung, E H; Zhang, C; Albert, P S et al. (2013) Adiposity and sex hormones across the menstrual cycle: the BioCycle Study. Int J Obes (Lond) 37:237-43
Chen, Liwei; Zhang, Cuilin; Yeung, Edwina et al. (2011) Age at menarche and metabolic markers for type 2 diabetes in premenopausal women: the BioCycle Study. J Clin Endocrinol Metab 96:E1007-12