The prevalence of obesity has been increasing alarmingly throughout the world and causes a multitude of comorbid conditions such as diabetes, cardiovascular disease, and cancer. The importance of genetic factors in determining susceptibility to obesity, in concert with environmental effects, has been well established. It is believed that many susceptibility genes may predispose to the common form of obesity, whereas the contribution of each gene is likely to be moderate. However, only a limited number of candidate genes for obesity were identified so far. Along with a multidisciplinary group of colleagues from Harvard University, Dr. Zhang is implementing a study to identify genetic factors of obesity and verify initial positive findings from GWAS of genetic variants that may determine abdominal adiposity in independent populations and to further examine the effect of gene-environment interactions. In the past year, several significant genetic factors were identified.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2013
Total Cost
$6,631
Indirect Cost
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State
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Zip Code
Yeung, E H; Zhang, C; Albert, P S et al. (2013) Adiposity and sex hormones across the menstrual cycle: the BioCycle Study. Int J Obes (Lond) 37:237-43
Qi, Lu; Cornelis, Marilyn C; Zhang, Cuilin et al. (2009) Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men. Am J Clin Nutr 89:1453-8
Cornelis, Marilyn C; Qi, Lu; Zhang, Cuilin et al. (2009) Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med 150:541-50
Heidemann, Christin; Sun, Qi; van Dam, Rob M et al. (2008) Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women. Ann Intern Med 149:307-16
Qi, Lu; Zhang, Cuilin; Greenberg, Andrew et al. (2008) Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women. Obesity (Silver Spring) 16:1061-5
Zhang, Cuilin; Qiu, Chunfang; Hu, Frank B et al. (2008) Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 3:e3753