The primary goal of this research is to identify significant modifiable factors (i.e., diet, lifestyle factors, etc.) and novel risk factors that may predict the risk for GDM and contribute to the prevention of GDM. Within the common theme of insulin resistance and secretion, several important diet and lifestyle associations with GDM have been successfully identified in this effort based on data from the Nurses Health Study II. Several studies on other modifiable risk factors and other novel risk factors are underway based on the Nurses'Health Study and other collaborative studies such as Consortium of Safe Labor. In the past year, we have identified several new risk factors including dietary protein intakes, history of infertility, history of depression, and environmental chemicals such as PFOA etc. These papers were presented in the Annual Scientific Meeting of American Diabetes Association, Society for Epidemiologic Research, and Society for Pediatric and Perinatal Research. We published several important papers on this topic as well.

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Bao, Wei; Tobias, Deirdre K; Olsen, Sjurdur F et al. (2014) Pre-pregnancy fried food consumption and the risk of gestational diabetes mellitus: a prospective cohort study. Diabetologia 57:2485-91
Hao, C; Zhang, C; Chen, W et al. (2014) Prevalence and risk factors of diabetes and impaired fasting glucose among university applicants in Eastern China: findings from a population-based study. Diabet Med 31:1194-8
Brite, J; Shiroma, E J; Bowers, K et al. (2014) Height and the risk of gestational diabetes: variations by race/ethnicity. Diabet Med 31:332-40
Tobias, Deirdre K; Chavarro, Jorge E; Williams, Michelle A et al. (2013) History of infertility and risk of gestational diabetes mellitus: a prospective analysis of 40,773 pregnancies. Am J Epidemiol 178:1219-25
Bowers, Katherine; Laughon, S Katherine; Kim, Sungduk et al. (2013) The association between a medical history of depression and gestational diabetes in a large multi-ethnic cohort in the United States. Paediatr Perinat Epidemiol 27:323-8
Yeung, E H; Zhang, C; Albert, P S et al. (2013) Adiposity and sex hormones across the menstrual cycle: the BioCycle Study. Int J Obes (Lond) 37:237-43
Zhang, Cuilin; Bao, Wei; Rong, Ying et al. (2013) Genetic variants and the risk of gestational diabetes mellitus: a systematic review. Hum Reprod Update 19:376-90
Bao, Wei; Bowers, Katherine; Tobias, Deirdre K et al. (2013) Prepregnancy dietary protein intake, major dietary protein sources, and the risk of gestational diabetes mellitus: a prospective cohort study. Diabetes Care 36:2001-8
Zhang, Cuilin; Qiu, Chunfang; Hu, Frank B et al. (2008) Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 3:e3753