The primary goal of this research is to identify significant modifiable factors (i.e., diet, lifestyle factors, etc.) and novel risk factors that may predict the risk for GDM and contribute to the prevention of GDM. Within the common theme of insulin resistance and secretion, several important diet and lifestyle associations with GDM have been successfully identified in this effort based on data from the Nurses Health Study II. Several studies on other modifiable risk factors and other novel risk factors are underway based on the Nurses'Health Study and other collaborative studies such as Consortium of Safe Labor. In the past year, we have identified several new risk factors including dietary protein intakes, history of infertility, history of depression, and environmental chemicals such as PFOA etc. These papers were presented in the Society of Maternal and Fetal Medicine meeting, Annual Scientific Meeting of American Diabetes Association, Society for Epidemiologic Research, and Society for Pediatric and Perinatal Research. We published several important papers on this topic as well. Seveeral papers are underreview.

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6
Fiscal Year
2014
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Indirect Cost
Name
U.S. National Inst/Child Hlth/Human Dev
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Mason, Susan M; Tobias, Deirdre K; Clark, Cari J et al. (2016) Abuse in Childhood or Adolescence and Gestational Diabetes: A Retrospective Cohort Study. Am J Prev Med 50:436-444
Smarr, Melissa M; Grantz, Katherine L; Zhang, Cuilin et al. (2016) Persistent organic pollutants and pregnancy complications. Sci Total Environ 551-552:285-91
Jaacks, Lindsay M; Barr, Dana Boyd; Sundaram, Rajeshwari et al. (2016) Pre-pregnancy maternal exposure to polybrominated and polychlorinated biphenyls and gestational diabetes: a prospective cohort study. Environ Health 15:11
Bao, Wei; Michels, Karin B; Tobias, Deirdre K et al. (2016) Parental smoking during pregnancy and the risk of gestational diabetes in the daughter. Int J Epidemiol 45:160-9
Zhang, Cuilin; Bao, Wei; Tobias, Deirdre K et al. (2016) Authors' reply to Gachi, Mullie and colleagues, and Weatherburn. BMJ 352:i1191
Chen, Liwei; Li, Shanshan; He, Chunyan et al. (2016) Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women. Diabetes Care 39:469-71
Zhang, Cuilin; Rawal, Shristi; Chong, Yap Seng (2016) Risk factors for gestational diabetes: is prevention possible? Diabetologia 59:1385-90
Bao, Wei; Tobias, Deirdre K; Hu, Frank B et al. (2016) Pre-pregnancy potato consumption and risk of gestational diabetes mellitus: prospective cohort study. BMJ 352:h6898
Bao, Wei; Baecker, Aileen; Song, Yiqing et al. (2015) Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: A systematic review. Metabolism 64:756-64
Zhang, Cuilin; Sundaram, Rajeshwari; Maisog, José et al. (2015) A prospective study of prepregnancy serum concentrations of perfluorochemicals and the risk of gestational diabetes. Fertil Steril 103:184-9

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