Air pollutants cause increased morbidity and mortality in the US, with an estimated 135,000 premature deaths due to ozone and particulate matter of 2.5 microns/cubic meter in 2005. Poor air quality has also been associated with adverse pregnancy outcomes including preterm delivery, restricted fetal growth/low birth weight and infant mortality. This project examines air quality measures in relation to menstrual/ovarian function and labor/delivery data to add to the literature on reproductive health outcomes associated with air pollutant exposures. Of particular interest are pregnancy outcomes for women with asthma, who may represent a vulnerable subgroup for the combined effects of poor air quality and asthma-related health effects and the novel assessment of hormone fluctuations associated with exposure to traffic and monitored air quality. Most prior studies of air pollution and pregnancy outcomes have been based on vital record data. This project represents an opportunity to evaluate labor and delivery complications on a broad national level and hormone measures that have not been previously studied. Exposure assessment is based on Community Multiscale Air Quality models.

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Mendola, Pauline; Wallace, Maeve; Liu, Danping et al. (2016) Air pollution exposure and preeclampsia among US women with and without asthma. Environ Res 148:248-55
Mendola, Pauline; Wallace, Maeve; Hwang, Beom Seuk et al. (2016) Preterm birth and air pollution: Critical windows of exposure for women with asthma. J Allergy Clin Immunol 138:432-440.e5
Wallace, Maeve E; Grantz, Katherine L; Liu, Danping et al. (2016) Exposure to Ambient Air Pollution and Premature Rupture of Membranes. Am J Epidemiol 183:1114-21
Zhu, Yeyi; Zhang, Cuilin; Liu, Danping et al. (2015) Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects. Environ Res 140:714-20
Männistö, Tuija; Mendola, Pauline; Liu, Danping et al. (2015) Acute air pollution exposure and blood pressure at delivery among women with and without hypertension. Am J Hypertens 28:58-72
Männistö, Tuija; Mendola, Pauline; Grantz, Katherine Laughon et al. (2015) Acute and recent air pollution exposure and cardiovascular events at labour and delivery. Heart 101:1491-8
Robledo, Candace A; Mendola, Pauline; Yeung, Edwina et al. (2015) Preconception and early pregnancy air pollution exposures and risk of gestational diabetes mellitus. Environ Res 137:316-22
Mendola, Pauline; Männistö, Tuija I; Leishear, Kira et al. (2014) Neonatal health of infants born to mothers with asthma. J Allergy Clin Immunol 133:85-90.e1-4
Rogalsky, Derek K; Mendola, Pauline; Metts, Tricia A et al. (2014) Estimating the number of low-income americans exposed to household air pollution from burning solid fuels. Environ Health Perspect 122:806-10
Mendola, Pauline; Laughon, S Katherine; Männistö, Tuija I et al. (2013) Obstetric complications among US women with asthma. Am J Obstet Gynecol 208:127.e1-8