In the x-ray area we have invented Fourier x-ray scattering imaging and published its physical principle and a first demonstration of biological application. We are working with Dr. Brad Wood of Clinical Center Radiology on the implementation of this technology to a clinical digital radiography unit. NIH Office of Technology Transfer has filed a provisional patent application on this technology. With Dr. Barry Lai and his colleagues at Argonne National Laboratory we explored a high resolution FSI device to be constructed at ANL. We have developed methods to remove artifacts in FSI images, and begun preparation for a rat osteoporosis study. Specifically to the rat study is a contract with a vendor to build a vertical FSI system. In the area of cardiovascular imaging, we have finished a project to improve the robustness of carotid artery wall strain imaging with a single-shot sequence and obtained data at both 1.5T and 3T in normal volunteers and in one stroke patient. The results are included in a manuscript near completion. We concluded the project to develop a displacement-encoded pulse sequence for simultaneous perfusion and strain imaging in the myocardial wall. This project included validation in a swine protocol and performance testing in acute myocardial infarction patients (STEMI). The manuscript has been reviewed and a revision has been submitted. We are currently working on a third project to improve signal processing in diffusion imaging.
| George, Alex; Chen, Peter Y; Morales-Martinez, Alejandro et al. (2017) Geometric calibration and correction for a lens-coupled detector in x-ray phase-contrast imaging. J Med Imaging (Bellingham) 4:013507 |
| Miao, Houxun; Panna, Alireza; Gomella, Andrew A et al. (2016) A Universal Moiré Effect and Application in X-Ray Phase-Contrast Imaging. Nat Phys 12:830-834 |
| Miao, Houxun; Chen, Lei; Mirzaeimoghri, Mona et al. (2016) Cryogenic Etching of High Aspect Ratio 400 nm Pitch Silicon Gratings. J Microelectromech Syst 25:963-967 |
| Miao, Houxun; Gomella, Andrew A; Harmon, Katherine J et al. (2015) Enhancing Tabletop X-Ray Phase Contrast Imaging with Nano-Fabrication. Sci Rep 5:13581 |
| Nayak, Krishna S; Nielsen, Jon-Fredrik; Bernstein, Matt A et al. (2015) Cardiovascular magnetic resonance phase contrast imaging. J Cardiovasc Magn Reson 17:71 |
| Harmon, Katherine J; Miao, Houxun; Gomella, Andrew A et al. (2015) Motionless electromagnetic phase stepping versus mechanical phase stepping in x-ray phase-contrast imaging with a compact source. Phys Med Biol 60:3031-43 |
| Harmon, Katherine J; Bennett, Eric E; Gomella, Andrew A et al. (2014) Efficient decoding of 2D structured illumination with linear phase stepping in X-ray phase contrast and dark-field imaging. PLoS One 9:e87127 |
| Wen, Han; Gomella, Andrew A; Patel, Ajay et al. (2014) Boosting phase contrast with a grating Bonse-Hart interferometer of 200 nanometre grating period. Philos Trans A Math Phys Eng Sci 372:20130028 |
| Miao, Houxun; Gomella, Andrew A; Chedid, Nicholas et al. (2014) Fabrication of 200 nm period hard X-ray phase gratings. Nano Lett 14:3453-8 |
| Wen, Han; Wolfe, Douglas E; Gomella, Andrew A et al. (2013) Interferometric hard x-ray phase contrast imaging at 204 nm grating period. Rev Sci Instrum 84:013706 |
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