Abstract

On the quest for high sensitivity x-ray phase-contrast imaging, we fabricated the first 200 nm period hard x-ray gratings and performed the first phase-contrast imaging experiments with such high density gratings in the world. We also proposed a new way of doing x-ray microscopy which is particularly suitable for biological samples and identified molecular probes for this technology. We invented a method to speed up x-ray phase-contrast imaging which is a significant challenge for clinical applications of this technology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHL004606-16
Application #
8557937
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
2012
Total Cost
$852,913
Indirect Cost

  Institution

Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

George, Alex; Chen, Peter Y; Morales-Martinez, Alejandro et al. (2017) Geometric calibration and correction for a lens-coupled detector in x-ray phase-contrast imaging. J Med Imaging (Bellingham) 4:013507
Miao, Houxun; Panna, Alireza; Gomella, Andrew A et al. (2016) A Universal Moiré Effect and Application in X-Ray Phase-Contrast Imaging. Nat Phys 12:830-834
Miao, Houxun; Chen, Lei; Mirzaeimoghri, Mona et al. (2016) Cryogenic Etching of High Aspect Ratio 400 nm Pitch Silicon Gratings. J Microelectromech Syst 25:963-967
Miao, Houxun; Gomella, Andrew A; Harmon, Katherine J et al. (2015) Enhancing Tabletop X-Ray Phase Contrast Imaging with Nano-Fabrication. Sci Rep 5:13581
Nayak, Krishna S; Nielsen, Jon-Fredrik; Bernstein, Matt A et al. (2015) Cardiovascular magnetic resonance phase contrast imaging. J Cardiovasc Magn Reson 17:71
Harmon, Katherine J; Miao, Houxun; Gomella, Andrew A et al. (2015) Motionless electromagnetic phase stepping versus mechanical phase stepping in x-ray phase-contrast imaging with a compact source. Phys Med Biol 60:3031-43
Harmon, Katherine J; Bennett, Eric E; Gomella, Andrew A et al. (2014) Efficient decoding of 2D structured illumination with linear phase stepping in X-ray phase contrast and dark-field imaging. PLoS One 9:e87127
Wen, Han; Gomella, Andrew A; Patel, Ajay et al. (2014) Boosting phase contrast with a grating Bonse-Hart interferometer of 200 nanometre grating period. Philos Trans A Math Phys Eng Sci 372:20130028
Miao, Houxun; Gomella, Andrew A; Chedid, Nicholas et al. (2014) Fabrication of 200 nm period hard X-ray phase gratings. Nano Lett 14:3453-8
Wen, Han; Miao, Houxun; Bennett, Eric E et al. (2013) Flexible retrospective phase stepping in x-ray scatter correction and phase contrast imaging using structured illumination. PLoS One 8:e78276

Showing the most recent 10 out of 28 publications