During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions. We have expanded a family of procedures in animal models to enter and exit the heart gracefully directly through the chest wall without surgical exposure. We intend these to allow large cardiovascular implants such as mitral valve replacements. We intend these also to allow direct repair of congenital heart defects on small children who otherwise might require open surgical access. NHLBI Cardiothoracic Surgery Research Branch investigators have used our interventional MRI system and environment to further test the feasibility and utility of real-time MRI guidance for surgical transapical implantation of a custom aortic stent valve bioprosthesis in swine. We have performed, for the first time, routine MRI-guided right heart catheterization in a series of patients. Overall we have successfully developed novel applications of real-time MRI for cardiovascular treatments, and we continue to work to clinical applications of these exciting new developments.

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National Heart, Lung, and Blood Institute
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Khan, Jaffar M; Rogers, Toby; Schenke, William H et al. (2016) Intentional Laceration of the Anterior Mitral Valve Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement: Pre-Clinical Findings. JACC Cardiovasc Interv 9:1835-43
Ratnayaka, Kanishka; Rogers, Toby; Schenke, William H et al. (2016) Magnetic Resonance Imaging-Guided Transcatheter Cavopulmonary Shunt. JACC Cardiovasc Interv 9:959-70
Campbell-Washburn, Adrienne E; Xue, Hui; Lederman, Robert J et al. (2016) Real-time distortion correction of spiral and echo planar images using the gradient system impulse response function. Magn Reson Med 75:2278-85
Wang, Dee Dee; Eng, Marvin; Greenbaum, Adam et al. (2016) Predicting LVOT Obstruction After TMVR. JACC Cardiovasc Imaging 9:1349-1352
McGuirt, Delaney; Mazal, Jonathan; Rogers, Toby et al. (2016) X-ray Fused With Magnetic Resonance Imaging to Guide Endomyocardial Biopsy of a Right Ventricular Mass. Radiol Technol 87:622-6
Rogers, Toby; Mahapatra, Srijoy; Kim, Steven et al. (2016) Transcatheter Myocardial Needle Chemoablation During Real-Time Magnetic Resonance Imaging: A New Approach to Ablation Therapy for Rhythm Disorders. Circ Arrhythm Electrophysiol 9:e003926
Mazal, Jonathan R; Rogers, Toby; Schenke, William H et al. (2016) Interventional-Cardiovascular MR: Role of the Interventional MR Technologist. Radiol Technol 87:261-70
Rogers, Toby; Ratnayaka, Kanishka; Schenke, William H et al. (2015) Intentional right atrial exit for microcatheter infusion of pericardial carbon dioxide or iodinated contrast to facilitate sub-xiphoid access. Catheter Cardiovasc Interv 86:E111-8
Lederman, Robert J; O'Neill, William W; Greenbaum, Adam B (2015) Transcaval access for TAVR across a polyester aortic graft. Catheter Cardiovasc Interv 85:1270-3
Rogers, Toby; Ratnayaka, Kanishka; Schenke, William H et al. (2015) Fully percutaneous transthoracic left atrial entry and closure as a potential access route for transcatheter mitral valve interventions. Circ Cardiovasc Interv 8:e002538

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