During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions. We have expanded a family of procedures in animal models to enter and exit the heart gracefully directly through the chest wall without surgical exposure. We intend these to allow large cardiovascular implants such as mitral valve replacements. We intend these also to allow direct repair of congenital heart defects on small children who otherwise might require open surgical access. NHLBI Cardiothoracic Surgery Research Branch investigators have used our interventional MRI system and environment to further test the feasibility and utility of real-time MRI guidance for surgical transapical implantation of a custom aortic stent valve bioprosthesis in swine. We have performed, for the first time, routine MRI-guided right heart catheterization in a series of patients. Overall we have successfully developed novel applications of real-time MRI for cardiovascular treatments, and we continue to work to clinical applications of these exciting new developments.

Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2011
Total Cost
$1,211,882
Indirect Cost
Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Campbell-Washburn, Adrienne E; Rogers, Toby; Stine, Annette M et al. (2018) Right heart catheterization using metallic guidewires and low SAR cardiovascular magnetic resonance fluoroscopy at 1.5 Tesla: first in human experience. J Cardiovasc Magn Reson 20:41
Fischer, Peter; Faranesh, Anthony; Pohl, Thomas et al. (2018) An MR-Based Model for Cardio-Respiratory Motion Compensation of Overlays in X-Ray Fluoroscopy. IEEE Trans Med Imaging 37:47-60
Kakareka, John W; Faranesh, Anthony Z; Pursley, Randall H et al. (2018) Physiological Recording in the MRI Environment (PRiME): MRI-Compatible Hemodynamic Recording System. IEEE J Transl Eng Health Med 6:4100112
Campbell-Washburn, Adrienne E; Tavallaei, Mohammad A; Pop, Mihaela et al. (2017) Real-time MRI guidance of cardiac interventions. J Magn Reson Imaging 46:935-950
Rogers, Toby; Ratnayaka, Kanishka; Khan, Jaffar M et al. (2017) CMR fluoroscopy right heart catheterization for cardiac output and pulmonary vascular resistance: results in 102 patients. J Cardiovasc Magn Reson 19:54
Ratnayaka, Kanishka; Moore, John W; Rios, Rodrigo et al. (2017) First-in-Human Closed-Chest Transcatheter Superior Cavopulmonary Anastomosis. J Am Coll Cardiol 70:745-752
Ratnayaka, Kanishka; Kanter, Joshua P; Faranesh, Anthony Z et al. (2017) Radiation-free CMR diagnostic heart catheterization in children. J Cardiovasc Magn Reson 19:65
McGuirt, Delaney; Mazal, Jonathan; Rogers, Toby et al. (2016) X-ray Fused With Magnetic Resonance Imaging to Guide Endomyocardial Biopsy of a Right Ventricular Mass. Radiol Technol 87:622-6
Ratnayaka, Kanishka; Rogers, Toby; Schenke, William H et al. (2016) Magnetic Resonance Imaging-Guided Transcatheter Cavopulmonary Shunt. JACC Cardiovasc Interv 9:959-70
Rogers, Toby; Lederman, Robert J (2016) Exercise Magnetic Resonance Imaging Is a Gas. Circ Cardiovasc Imaging 9:

Showing the most recent 10 out of 70 publications