During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions. We have introduced MRI catheterization into standard clinical practice at the NIH clinical center, based on our earlier careful pilot research comparison of conventional X-ray and wholly MRI guided transfemoral pulmonary artery catheterization in adults. We continue to enhance the capabilities of MRI catheterization to characterize heart function in patients. We continue to test MRI pericardiocentesis procedure in humans. We are developing new approaches to connect different heart chambers without surgery in patients with congenital heart disease. We also continue work towards direct repair of congenital heart defects on small children who otherwise might require open surgical access. We are developing other novel catheterization tools, for example, to access the aorta without surgery in patients with severe peripheral artery disease. Recently these have been tested in patients by collaborators outside the NIH. NHLBI Cardiothoracic Surgery Research Branch investigators have used our interventional MRI system and environment to further test the feasibility and utility of real-time MRI guidance for surgical transapical implantation of a custom aortic stent valve bioprosthesis in swine. Overall we have successfully developed novel applications of real-time MRI for cardiovascular treatments, and we continue to work to clinical applications of these exciting new developments.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Heart, Lung, and Blood Institute
Zip Code
Rogers, Toby; Ratnayaka, Kanishka; Lederman, Robert J (2014) MRI catheterization in cardiopulmonary disease. Chest 145:30-6
Lederman, Robert J; Rogers, Toby; Faranesh, Anthony Z (2014) Letter by Lederman et al regarding article, "MRI-induced stent dislodgment soon after left main coronary artery stenting". Circ Cardiovasc Interv 7:128
Sinha, Pranava; Deutsch, Nina; Ratnayaka, Kanishka et al. (2014) Effect of mechanical assistance of the systemic ventricle in single ventricle circulation with cavopulmonary connection. J Thorac Cardiovasc Surg 147:1271-5
Halabi, Majdi; Ratnayaka, Kanishka; Faranesh, Anthony Z et al. (2013) Transthoracic delivery of large devices into the left ventricle through the right ventricle and interventricular septum: preclinical feasibility. J Cardiovasc Magn Reson 15:10
Faranesh, Anthony Z; Kellman, Peter; Ratnayaka, Kanishka et al. (2013) Integration of cardiac and respiratory motion into MRI roadmaps fused with x-ray. Med Phys 40:032302
Halabi, Majdi; Faranesh, Anthony Z; Schenke, William H et al. (2013) Real-time cardiovascular magnetic resonance subxiphoid pericardial access and pericardiocentesis using off-the-shelf devices in swine. J Cardiovasc Magn Reson 15:61
Barbash, I M; Cecchini, S; Faranesh, A Z et al. (2013) MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Gene Ther 20:274-82
Ratnayaka, Kanishka; Faranesh, Anthony Z; Hansen, Michael S et al. (2013) Real-time MRI-guided right heart catheterization in adults using passive catheters. Eur Heart J 34:380-9
Wu, Vincent; Barbash, Israel M; Ratnayaka, Kanishka et al. (2011) Adaptive noise cancellation to suppress electrocardiography artifacts during real-time interventional MRI. J Magn Reson Imaging 33:1184-93
Ratnayaka, Kanishka; Raman, Venkatesh K; Faranesh, Anthony Z et al. (2009) Antegrade percutaneous closure of membranous ventricular septal defect using X-ray fused with magnetic resonance imaging. JACC Cardiovasc Interv 2:224-30

Showing the most recent 10 out of 17 publications