During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions. We have introduced MRI catheterization into standard clinical practice at the NIH clinical center, based on our earlier careful pilot research comparison of conventional X-ray and wholly MRI guided transfemoral pulmonary artery catheterization in adults. We continue to enhance the capabilities of MRI catheterization to characterize heart function in patients. We continue to test MRI pericardiocentesis procedure in humans. We are developing new approaches to connect different heart chambers without surgery in patients with congenital heart disease. We also continue work towards direct repair of congenital heart defects on small children who otherwise might require open surgical access. We are developing other novel catheterization tools, for example, to access the aorta without surgery in patients with severe peripheral artery disease. Recently these have been tested in patients by collaborators outside the NIH. NHLBI Cardiothoracic Surgery Research Branch investigators have used our interventional MRI system and environment to further test the feasibility and utility of real-time MRI guidance for surgical transapical implantation of a custom aortic stent valve bioprosthesis in swine. Overall we have successfully developed novel applications of real-time MRI for cardiovascular treatments, and we continue to work to clinical applications of these exciting new developments.

Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2013
Total Cost
$1,194,579
Indirect Cost
Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
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Zip Code
Khan, Jaffar M; Rogers, Toby; Schenke, William H et al. (2016) Intentional Laceration of the Anterior Mitral Valve Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement: Pre-Clinical Findings. JACC Cardiovasc Interv 9:1835-43
Ratnayaka, Kanishka; Rogers, Toby; Schenke, William H et al. (2016) Magnetic Resonance Imaging-Guided Transcatheter Cavopulmonary Shunt. JACC Cardiovasc Interv 9:959-70
Campbell-Washburn, Adrienne E; Xue, Hui; Lederman, Robert J et al. (2016) Real-time distortion correction of spiral and echo planar images using the gradient system impulse response function. Magn Reson Med 75:2278-85
Wang, Dee Dee; Eng, Marvin; Greenbaum, Adam et al. (2016) Predicting LVOT Obstruction After TMVR. JACC Cardiovasc Imaging 9:1349-1352
McGuirt, Delaney; Mazal, Jonathan; Rogers, Toby et al. (2016) X-ray Fused With Magnetic Resonance Imaging to Guide Endomyocardial Biopsy of a Right Ventricular Mass. Radiol Technol 87:622-6
Rogers, Toby; Mahapatra, Srijoy; Kim, Steven et al. (2016) Transcatheter Myocardial Needle Chemoablation During Real-Time Magnetic Resonance Imaging: A New Approach to Ablation Therapy for Rhythm Disorders. Circ Arrhythm Electrophysiol 9:e003926
Mazal, Jonathan R; Rogers, Toby; Schenke, William H et al. (2016) Interventional-Cardiovascular MR: Role of the Interventional MR Technologist. Radiol Technol 87:261-70
Rogers, Toby; Ratnayaka, Kanishka; Schenke, William H et al. (2015) Intentional right atrial exit for microcatheter infusion of pericardial carbon dioxide or iodinated contrast to facilitate sub-xiphoid access. Catheter Cardiovasc Interv 86:E111-8
Lederman, Robert J; O'Neill, William W; Greenbaum, Adam B (2015) Transcaval access for TAVR across a polyester aortic graft. Catheter Cardiovasc Interv 85:1270-3
Rogers, Toby; Ratnayaka, Kanishka; Schenke, William H et al. (2015) Fully percutaneous transthoracic left atrial entry and closure as a potential access route for transcatheter mitral valve interventions. Circ Cardiovasc Interv 8:e002538

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