The 5A amphipathic peptide, which was shown earlier by our laboratory to be specific for removing cholesterol by the ABCA1 transporter, was tested in a mouse model of atherosclerosis and was found to be protective (ref. 1). In a rabbit vascular collar model, it was found to reduce inflammation (ref. 4). In collaboration with Dr. Stewart Levine, we showed in a mouse model of asthma, it also reduced inflammation associated with asthma (J Immunol 2011;86:576). In the past year, we have also developed new single helical peptides containing a hydrocarbon staple that enhanced the cholesterol efflux potential of these peptides and made them resistant to gastric and intestinal proteolysis, thus potentially making these peptides orally available (BBRC 2011:10:446). The 5A peptide was licensed to an outside company for further drug development.

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2011
Total Cost
$688,623
Indirect Cost
Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Gordon, Scott M; Remaley, Alan T (2017) High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis. Atherosclerosis 259:104-113
Remaley, Alan T (2015) HDL cholesterol/HDL particle ratio: a new measure of HDL function? J Am Coll Cardiol 65:364-6
Sviridov, Dmitri; Remaley, Alan T (2015) High-density lipoprotein mimetics: promises and challenges. Biochem J 472:249-59
Amar, Marcelo J A; Sakurai, Toshihiro; Sakurai-Ikuta, Akiko et al. (2015) A novel apolipoprotein C-II mimetic peptide that activates lipoprotein lipase and decreases serum triglycerides in apolipoprotein E-knockout mice. J Pharmacol Exp Ther 352:227-35
Liu, Zheng; Thacker, Seth G; Fernandez-Castillejo, Sara et al. (2014) Synthesis of cholesterol analogues bearing BODIPY fluorophores by Suzuki or Liebeskind-Srogl cross-coupling and evaluation of their potential for visualization of cholesterol pools. Chembiochem 15:2087-96
Dai, Cuilian; Yao, Xianglan; Vaisman, Boris et al. (2014) ATP-binding cassette transporter 1 attenuates ovalbumin-induced neutrophilic airway inflammation. Am J Respir Cell Mol Biol 51:626-36
Vickers, Kasey C; Remaley, Alan T (2014) HDL and cholesterol: life after the divorce? J Lipid Res 55:4-12
Ditiatkovski, Michael; D'Souza, Wilissa; Kesani, Rajitha et al. (2013) An apolipoprotein A-I mimetic peptide designed with a reductionist approach stimulates reverse cholesterol transport and reduces atherosclerosis in mice. PLoS One 8:e68802
Remaley, Alan T (2013) Apolipoprotein A-II: still second fiddle in high-density lipoprotein metabolism? Arterioscler Thromb Vasc Biol 33:166-7
Vickers, Kasey C; Sethupathy, Praveen; Baran-Gale, Jeanette et al. (2013) Complexity of microRNA function and the role of isomiRs in lipid homeostasis. J Lipid Res 54:1182-91

Showing the most recent 10 out of 24 publications